TOP > 外国特許検索 > CD20-NEGATIVELY CONVERTED B CELL MALIGNANT LYMPHOCYTE CELL LINE AND UTILIZATION OF THE SAME

CD20-NEGATIVELY CONVERTED B CELL MALIGNANT LYMPHOCYTE CELL LINE AND UTILIZATION OF THE SAME

外国特許コード F080001865
整理番号 F080001865
掲載日 2008年5月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2007JP068370
国際公開番号 WO 2008/038587
国際出願日 平成19年9月21日(2007.9.21)
国際公開日 平成20年4月3日(2008.4.3)
優先権データ
  • 特願2006-259355 (2006.9.25) JP
発明の名称 (英語) CD20-NEGATIVELY CONVERTED B CELL MALIGNANT LYMPHOCYTE CELL LINE AND UTILIZATION OF THE SAME
発明の概要(英語) It is intended to provide a tool, a procedure and so on which are useful in developing a therapeutic strategy efficacious in inhibiting or overcoming the resistance against a CD20-directed molecular-targeted drug. Thus, a CD20-negatively converted B cell malignant lymphocyte cell line is provided. Also, a model animal indicating the pathological conditions of CD20-negatively converted B cell malignant lymphocyte is provided. Further, a method of screening a substance, which is efficacious against CD20 positive B cell malignant lymphocyte or CD20-negatively converted B cell malignant lymphocyte, is provided. Furthermore, a drug against CD20 positive B cell malignant lymphocyte or CD20-negatively converted B cell malignant lymphocyte, which is characterized by being used together with a CD20-directed molecular-targeted drug, is provided. In one embodiment, a DNA methylase inhibitor or a histone deacetylase inhibitor is employed as the active ingredient.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • National University Corporation Nagoya University
  • 発明者(英語)
  • Naoe, Tomoki
  • Tomita, Akihiro
  • Hiraga, Junji
国際特許分類(IPC)
指定国 AE AG AL AM AT AU AZ BA BB BE BF BG BH BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DO DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GT GW HN HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LV LY MA MC MD ME MG MK ML MN MR MT MW MX MY MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SI SK SL SM SN SV SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
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