TOP > 外国特許検索 > PROCESS FOR PRODUCTION OF DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALYST, PROCESS FOR PRODUCTION OF β-AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE SALT

PROCESS FOR PRODUCTION OF DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALYST, PROCESS FOR PRODUCTION OF β-AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE SALT コモンズ

外国特許コード F090002113
整理番号 F090002113
掲載日 2009年7月10日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2008JP067854
国際公開番号 WO 2009/054240
国際出願日 平成20年10月1日(2008.10.1)
国際公開日 平成21年4月30日(2009.4.30)
優先権データ
  • 特願2007-276590 (2007.10.24) JP
  • 特願2007-276589 (2007.10.24) JP
発明の名称 (英語) PROCESS FOR PRODUCTION OF DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALYST, PROCESS FOR PRODUCTION OF β-AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE SALT コモンズ
発明の概要(英語) Hexamethylphosphoramide (HMPA) is added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The reaction vessel is purged with oxygen, and is stirred at 80°C for 5 days under 7 atmospheres of oxygen. The reaction solution is cooled to room temperature and subsequently purified, thereby producing potassium (R)-1,1'-binaphthyl-2,2'-disulfonate. (R)-1,1'-Binaphthyl-2,2'-disulfonic acid produced from the disulfonate salt and 2,6-diphenylpyridine are stirred together in acetonitrile, and the solvent is distilled away from the reaction solution under reduced pressure. Subsequently, magnesium sulfate and distilled CH2Cl2 are added to the reaction product, and the resulting mixture is stirred at room temperature for 30 minutes. The solution is cooled to 0°C, and benzaldehydimine in which nitrogen is protected with Cbz and acethylacetone are added thereto dropwise over 1 hour. The resulting mixture is further stirred at 0°C for 30 minutes. In this manner, a corresponding β-aminocarbonyl derivative can be produced in an yield of 91% and at a rate of enantiomeric excess of 90% ee.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • National University Corporation Nagoya University
  • 発明者(英語)
  • Ishihara, Kazuaki
  • Hatano, Manabu
  • Maki, Toshikatsu
国際特許分類(IPC)
指定国 AE AG AL AM AO AT AU AZ BA BB BE BF BG BH BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DO DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GT GW HN HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LV LY MA MC MD ME MG MK ML MN MR MT MW MX MY MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SI SK SL SM SN ST SV SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
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