TOP > 外国特許検索 > DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY USING THE SAME

DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY USING THE SAME

外国特許コード F090002138
整理番号 F090002138
掲載日 2009年12月11日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2008JP062297
国際公開番号 WO 2009/008412
国際出願日 平成20年7月7日(2008.7.7)
国際公開日 平成21年1月15日(2009.1.15)
優先権データ
  • 60/929,662 (2007.7.6) US
発明の名称 (英語) DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY USING THE SAME
発明の概要(英語) Disclosed are a DNA chip and a prediction method for predicting the occurrence of a late adverse reaction in a urinary organ after C-ion RT. The DNA chip comprises a supporting means for supporting a DNA probe thereon; and two or more genetic markers supported on the supporting means. The prediction method comprises: a first step of hybridizing a genetic marker with labeled DNA prepared from a subject to be examined; a second step of identifying nucleotides of both alleles of the labeled DNA hybridized with the genetic marker; and a third step of determining the combination of the identified nucleotides of both alleles of the labeled DNA as being a risk genotype when the combination of the identified nucleotides corresponds to a specified combination, and predicting that the subject is predisposed to develop a late adverse reaction in a urinary organ after radiation therapy when the number of the risk genotypes is three or more and that the subject is not predisposed to develop a late adverse reaction in a urinary organ after radiation therapy when the number of the risk genotypes is two or less. The method enables to predict whether or not a subject is affected with a late adverse reaction in a urinary organ after radiation therapy.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • National Institute Of Radiological Sciences
  • 発明者(英語)
  • Imai, Takashi
  • Iwakawa, Mayumi
  • Oda, Eisei
国際特許分類(IPC)
指定国 AE AG AL AM AO AT AU AZ BA BB BE BF BG BH BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DO DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GT GW HN HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LV LY MA MC MD ME MG MK ML MN MR MT MW MX MY MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SI SK SL SM SN ST SV SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
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