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Methods of using TICAM-1, an adapter protein that binds toll-like receptor 3

外国特許コード F110003337
整理番号 A211-02US2
掲載日 2011年6月23日
出願国 アメリカ合衆国
出願番号 38512709
公報番号 20100087510
公報番号 08029778
出願日 平成21年3月31日(2009.3.31)
公報発行日 平成22年4月8日(2010.4.8)
公報発行日 平成23年10月4日(2011.10.4)
国際出願番号 PCT/JP03/14854
国際出願日 平成15年11月20日(2003.11.20)
優先権データ
  • 特願2002-349015 (2002.11.29) JP
発明の名称 (英語) Methods of using TICAM-1, an adapter protein that binds toll-like receptor 3
発明の概要(英語) A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is effective for prevention/treatment of viral infectious disease such as hepatitis B, hepatitis C, and the like, treatment of tumors, and the other purposes. Novel adaptor protein TICAM-1, which has an amino acid sequence set forth in SEQ ID NO: 2 or 4, specifically binds to the mammalian Toll-like receptor 3 and induces production of type I interferon. A mutant of the adaptor protein TICAM-1 has similar properties, provided that it has TIR domain (an amino acid sequence ranging from 394-position to 532-position in the amino acid sequence set forth in SEQ ID NO: 2 or an amino acid sequence ranging 396-position to 534-position in the amino acid sequence set forth in SEQ ID NO: 4). The gene is a gene encoding the adaptor protein TICAM-1.
  • 発明者/出願人(英語)
  • Seya, Tsukasa; Sapporo [JP]
  • Matsumoto, Misako; Sapporo [JP]
  • Oshiumi, Hiroyuki; Osaka [JP]
  • Japan Science and Technology Agency, Saitama [JP]
国際特許分類(IPC)
米国特許分類/主・副
  • 424/93.2
  • 435/70.1
  • 435/70.3
  • 435/455
  • 435/69.1
  • 435/7.21
  • 530/351
  • 536/23.5
参考情報 (研究プロジェクト等) CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA
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