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Method for promoting immune response comprising inhibiting CD22 function in B cells

外国特許コード F110003467
整理番号 A261-09WO
掲載日 2011年6月27日
出願国 アメリカ合衆国
出願番号 51613407
公報番号 20100063130
公報番号 9018245
出願日 平成19年12月21日(2007.12.21)
公報発行日 平成22年3月11日(2010.3.11)
公報発行日 平成27年4月28日(2015.4.28)
国際出願番号 JP2007074634
国際公開番号 WO2008078673
国際出願日 平成19年12月21日(2007.12.21)
国際公開日 平成20年7月3日(2008.7.3)
優先権データ
  • 特願2006-349458 (2006.12.26) JP
  • 2007JP074634 (2007.12.21) WO
発明の名称 (英語) Method for promoting immune response comprising inhibiting CD22 function in B cells
発明の概要(英語) The purpose of the present invention is to elucidate a relationship between deregulation of signaling by CD22 and a rapid response of B cells by IgG-BCR and the like, and to provide a method capable of inducing a rapid immune response and defending against infection instead of vaccine.
The present invention relates to a method for promoting an immune response causing such a strong proliferation of clones and production of a large amount of antibody-producing cells as those seen in the memory immune response even in the naive B cells expressing IgM-BCR and IgD-BCR by inhibiting the CD22 function in B cells; and to a method for screening a substance capable of promoting the immune response based on a change in the CD22 function in B cells.
特許請求の範囲(英語) [claim1]
1. A method of screening for a substance inhibiting that inhibits CD22 expression, comprising: (a) contacting said substance with cultured IgM or IgD positive naive B cells;
(b) measuring CD22 expression in said naïve B cells following said contacting step;
(c) comparing CD22 expression in step (b) with CD22 expression in control IgM or IgD positive naïve B cells; and
(d) determining whether said substance inhibits CD22 expression in said cultured IgM or IgD positive naive B cells relative to the control naïve B cells; and
(e) selecting the substance as a substance that promotes an early stage immune response based on said inhibition of CD22 expression in said cultured IgM or IgD positive naïve B cells relative to the control naïve B cells.
[claim2]
2. The method according to claim 1, wherein the method further comprises the step of measuring proliferation or survival of said B cells.
[claim3]
3. The method according to claim 1, wherein the method further comprises the step of treating the cells with an antigen.
[claim4]
4. The method according to claim 1, wherein the B cells are from a mouse.
[claim5]
5. The method according to claim 1, wherein the B cells are from a human.
  • 発明者/出願人(英語)
  • TSUBATA TAKESHI
  • ONODERA TAISHI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 514/440
  • 435/7.1
  • 435/7.2
  • 435/7.21
  • 435/7.24
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA
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