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Method for preparing porous composite material

外国特許コード F110003480
整理番号 A122-29EP
掲載日 2011年6月28日
出願国 欧州特許庁(EPO)
出願番号 02722917
公報番号 1500405
公報番号 1500405
出願日 平成14年5月1日(2002.5.1)
公報発行日 平成17年1月26日(2005.1.26)
公報発行日 平成26年3月5日(2014.3.5)
国際出願番号 JP2002004355
国際公開番号 WO2003092759
国際出願日 平成14年5月1日(2002.5.1)
国際公開日 平成15年11月13日(2003.11.13)
優先権データ
  • 2002JP004355 (2002.5.1) WO
発明の名称 (英語) Method for preparing porous composite material
発明の概要(英語) This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant.
The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability.
Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
特許請求の範囲(英語) [claim1]
1. A process for producing porous and composite materials comprising steps of: heating a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen for a reaction time between 60 to 120 min and at a reaction temperature between 35 deg.C and 45 deg.C with adding acid or for a reaction time between 60 to 120 min and at a reaction temperature between 40 deg.C and 50 deg.C without adding acid thereby gelatinizing at least a part of the collagen, cooling the heated complex until the complex gels, to provide a gelled complex; freezing the gelled complex; and then lyophilizing the resultant to produce porous and composite materials.
[claim2]
2. The process for producing porous and composite materials according to claim 1, wherein said process comprises a step of introducing surface crosslinking into at least 1% of the reactive groups of collagens on said porous and composite materials produced, wherein the surface crosslinking is introduced between collagens that are present on the surface of the porous and composite materials.
[claim3]
3. The process according to claim 2, wherein the step of introducing surface crosslinking is carried out by immersing the porous and composite materials in a solution containing 0,001% to 1% of glutaraldehyde as a crosslinking agent for 60 minutes to 5 hours.
[claim4]
4. The process according to any one of claims 1 to 3 comprising a step of adding a crosslinking agent to gelatinized collagen to introduce internal crosslinking between collagens, wherein the internal crosslinking is introduced between collagens that are present in the complex.
[claim5]
5. The process according to any one of claims 1 to 4, wherein the calcium salt is hydroxyapatite.
[claim6]
6. The process according to any one of claims 2 to 5, wherein internal and/or surface crosslinking between collagens is introduced using glutaraldehyde as a crosslinking agent.
[claim7]
7. The process according to any one of claims 2 to 6, wherein surface crosslinking between collagens is introduced by immersing the porous and composite materials in a solution containing a crosslinking agent comprising ethanol as a solvent.
[claim8]
8. The process according to any one of claims 1 to 7, wherein the resulting porous and composite materials have porosities of 80% or higher.
[claim9]
9. The process according to any one of claims 1 to 8 using a complex comprising the c-axis of hydroxyapatite being oriented along collagen fibers.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  • 発明者(英語)
  • SOTOME SHINICHI
  • UEMURA TOSHIMASA
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TATEISHI TETSUYA
国際特許分類(IPC)
欧州特許分類/主・副
  • A61L027/46
  • A61L027/56
指定国 Contracting States: DE FR GB
参考情報 (研究プロジェクト等) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
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