TOP > 外国特許検索 > Process of making alpha -aminooxyketone/alpha -aminooxyaldehyde and alpha -hydroxyketone/alpha -hydroxyaldehyde compounds and a process making reaction products from cyclic alpha ,beta -unsaturated ketone substrates and nitroso substrates

Process of making alpha -aminooxyketone/alpha -aminooxyaldehyde and alpha -hydroxyketone/alpha -hydroxyaldehyde compounds and a process making reaction products from cyclic alpha ,beta -unsaturated ketone substrates and nitroso substrates

外国特許コード F110003522
整理番号 B12-03WO
掲載日 2011年6月28日
出願国 アメリカ合衆国
出願番号 50659006
公報番号 20070037973
公報番号 07872123
出願日 平成18年8月18日(2006.8.18)
公報発行日 平成19年2月15日(2007.2.15)
公報発行日 平成23年1月18日(2011.1.18)
国際出願番号 PCT/US2005/005426
国際出願日 平成17年2月18日(2005.2.18)
優先権データ
  • 特願2004-044540 (2004.2.20) JP
発明の名称 (英語) Process of making alpha -aminooxyketone/alpha -aminooxyaldehyde and alpha -hydroxyketone/alpha -hydroxyaldehyde compounds and a process making reaction products from cyclic alpha ,beta -unsaturated ketone substrates and nitroso substrates
発明の概要(英語) The present invention is directed to a process of making alpha -aminooxyketone and alpha -hydroxyketone compounds. The synthetic pathway involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV):wherein Xa-Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the alpha -aminooxyketone compound formed to the alpha -hydroxyketone compound which results in alpha -aminooxyketone and alpha -hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol/Michael reaction involving a cyclic alpha ,beta -unsaturated ketone substrate and a nitroso substrate. This methodology involves reacting the cyclic alpha ,beta -unsaturated ketone substrate and the nitroso substrate in the presence of a proline-based catalyst, to provide a heterocyclic product.
  • 発明者/出願人(英語)
  • Momiyama, Norie; Sendai [JP]
  • Torii, Hiromi; Kariya [JP]
  • Saito, Susumu; Nagoya [JP]
  • Yamamoto, Hisashi; Chicago IL [US]
  • Yamamoto, Yuhei; Tsukuba [JP]
  • Japan Science And Technology Agency, Saitama [JP]
国際特許分類(IPC)
米国特許分類/主・副
  • 544/63
参考情報 (研究プロジェクト等) SORST Selected in Fiscal 2000
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