TOP > 外国特許検索 > METHOD OF SCREENING INHIBITOR BY USING INDUCTION OF INTERLEUKIN 18 PRODUCTION BY KERATINOCYTE, METHOD OF INDUCING ATOPIC DERMATITIS-LIKE SYMPTOM AND UTILIZATION OF THE SAME

METHOD OF SCREENING INHIBITOR BY USING INDUCTION OF INTERLEUKIN 18 PRODUCTION BY KERATINOCYTE, METHOD OF INDUCING ATOPIC DERMATITIS-LIKE SYMPTOM AND UTILIZATION OF THE SAME

外国特許コード F110003616
整理番号 A211-03WO
掲載日 2011年6月30日
出願国 欧州特許庁(EPO)
出願番号 04728686
公報番号 1635176
公報番号 1635176
出願日 平成16年4月21日(2004.4.21)
公報発行日 平成18年3月15日(2006.3.15)
公報発行日 平成25年5月22日(2013.5.22)
国際出願番号 WO2004JP05747
国際出願日 平成16年4月21日(2004.4.21)
優先権データ
  • 特願2003-120630 (2003.4.24) JP
発明の名称 (英語) METHOD OF SCREENING INHIBITOR BY USING INDUCTION OF INTERLEUKIN 18 PRODUCTION BY KERATINOCYTE, METHOD OF INDUCING ATOPIC DERMATITIS-LIKE SYMPTOM AND UTILIZATION OF THE SAME
発明の概要(英語)

The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.

  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • NAKANISHI, KENJI
  • MIZUTANI, HITOSHI
  • TSUTSUI, HIROKO
国際特許分類(IPC)
指定国 CH,DE,FR,GB,IT,LI
参考情報 (研究プロジェクト等) CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA
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