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Random copolymer of oxazoline

外国特許コード F110003658
整理番号 A252-32WO
掲載日 2011年6月30日
出願国 欧州特許庁(EPO)
出願番号 06797486
公報番号 1930361
公報番号 1930361
出願日 平成18年8月30日(2006.8.30)
公報発行日 平成20年6月11日(2008.6.11)
公報発行日 平成26年4月16日(2014.4.16)
国際出願番号 JP2006317587
国際公開番号 WO2007026932
国際出願日 平成18年8月30日(2006.8.30)
国際公開日 平成19年3月8日(2007.3.8)
優先権データ
  • 2006JP317587 (2006.8.30) WO
  • 特願2005-253977 (2005.9.1) JP
発明の名称 (英語) Random copolymer of oxazoline
発明の概要(英語) The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator.
Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.(see diagramm)
特許請求の範囲(英語) [claim1]
1. A random copolymer represented by the following formula (A): (see diagramm) in the formula, In stands for a residue of a cationic polymerization initiator, NP stands for a residue of a nucleophilic agent, and m and n are integers of 5 - 10,000 independently of each other, m + n being an integer of 10 - 20,000 and m:n being, in terms of a molar ratio, 1:99 - 99:1, wherein the cloud point of a 1 wt. % aqueous solution of the copolymer is controlled to a value within a range of 37 deg.C - 67 deg.C, and the degree of dispersion (Mw/Mn) is not more than 1.15.
[claim2]
2. The random copolymer according to Claim 1, in which m + n is an integer of 10 - 200, and m:n in terms of a molar ratio is 10:90 - 90:10.
[claim3]
3. The random copolymer according to Claim 1, in which the residue of the cationic polymerization initiator is a substituted or unsubstituted straight chain or branched C 1-20 alkyl, and the residue of the nucleophilic agent is selected from the group consisting of -OH, -SH, -NH 2, -CN, -COOH, -OCOC(CH 3) = CH 2, -OCOCH = CH 2 and -OCH 2CH = CH 2.
[claim4]
4. The random copolymer according to Claim 3, in which the substituent on the substituted straight chain or branched C 1-20 alkyl is represented by the formula: (see diagramm) or the formula:

R **3C ≡ C-,

wherein R **1 and R **2 either stand for C 1-10 alkoxy, aryloxy or aryl-C 1-3 alkyloxy, independently of each other, or R **1 and R **2 together stand for optionally C 1-5 alkyl-substituted ethylenedioxy (-O-CH(R')-CH 2-O-, R' being hydrogen or C 1-5 alkyl) or oxy (=0) group, and
R **3 stands for hydrogen or C 1-5 alkyl.
[claim5]
5. A production method of a random copolymer represented by the formula (A): (see diagramm) in the formula, In stands for a residue of a cationic polymerization initiator, NP stands for a residue of a nucleophilic agent, and m and n are integers of 5 - 10,000 independently of each other, m + n being an integer of 10 - 20,000 and m:n being, in terms of a molar ratio, 1:99 - 99:1, wherein the cloud point of a 1 wt.% aqueous solution of the copolymer is controlled to a value within a range of 37 deg.C - 67 deg.C, and the degree of dispersion (Mw/Mn) is not more than 1.15,
which comprises a step of ring-opening polymerizing a monomeric mixture of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline at a molar ratio of 1:99 - 99:1 in an inert solvent at 35 deg.C - 45 deg.C in the presence of a cationic polymerization initiator, a step of reacting the resultant random copolymer with a nucleophilic agent, and, where necessary, a step of isolating the formed polymer.
[claim6]
6. The production method according to Claim 5, in which the cationic polymerization initiator is a substituted or unsubstituted, straight chain or branched C 1-20 alkyl tosylate.
[claim7]
7. The production method according to Claim 6, in which the substituent on the substituted straight chain or branched C 1-20 alkyl is represented by the formula: (see diagramm) or the formula:

R **3C ≡ C-,

wherein R **1 and R **2 either stand for C 1-10 alkoxy, aryloxy or aryl-C 1-3 alkyloxy, independently of each other, or R **1 and R **2 together stand for optionally C 1-5 alkyl-substituted ethylenedioxy (-O-CH(R')-CH 2-O-, R' being hydrogen or C 1-5 alkyl) or oxy (=0) group, and
R **3 stands for hydrogen or C 1-5 alkyl.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KATAOKA KAZUNORI
  • YAMASAKI YUICHI
  • PARK JOON-SIK
国際特許分類(IPC)
欧州特許分類/主・副
  • C08G073/02E
指定国 Contracting States: DE FR GB
参考情報 (研究プロジェクト等) CREST Creation of Bio-Devices and Bio-Systems with Chemical and Biological Molecules for Medical Use AREA
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