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Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore

外国特許コード F110003812
整理番号 E07612WO
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 79552506
公報番号 20080139835
公報番号 07541307
出願日 平成19年7月18日(2007.7.18)
公報発行日 平成20年6月12日(2008.6.12)
公報発行日 平成21年6月2日(2009.6.2)
国際出願番号 PCT/JP2006/301293
国際公開番号 WO2006/080425
国際出願日 平成18年1月27日(2006.1.27)
国際公開日 平成18年8月3日(2006.8.3)
優先権データ
  • 特願2005-022643 (2005.1.31) JP
発明の名称 (英語) Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore
発明の概要(英語) A silicon enolate represented by the following formula (Formula 1)(in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.(in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.
  • 発明者/出願人(英語)
  • Kobayashi, Shu; Tokyo [JP]
  • Manabe, Kei; Tokyo [JP]
  • Japan Science and Technology Agency, Saitama [JP]
国際特許分類(IPC)
米国特許分類/主・副
  • 502/167
参考情報 (研究プロジェクト等) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
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