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NUCLEIC ACID CAPABLE OF BINDING SPECIFICALLY TO Ras TARGET PROTEIN

外国特許コード F110003870
整理番号 E04801EP
掲載日 2011年7月6日
出願国 欧州特許庁(EPO)
出願番号 99937069
公報番号 1026243
公報番号 1026243
出願日 平成11年8月13日(1999.8.13)
公報発行日 平成12年8月9日(2000.8.9)
公報発行日 平成18年2月1日(2006.2.1)
国際出願番号 JP1999004399
国際公開番号 WO2000009684
国際出願日 平成11年8月13日(1999.8.13)
国際公開日 平成12年2月24日(2000.2.24)
優先権データ
  • 1999JP004399 (1999.8.13) WO
  • 特願1998-242596 (1998.8.14) JP
  • 特願1998-333284 (1998.11.24) JP
発明の名称 (英語) NUCLEIC ACID CAPABLE OF BINDING SPECIFICALLY TO Ras TARGET PROTEIN
発明の概要(英語) A novel nucleic acid (aptamer) which binds specifically to the target protein of Ras, more particularly, a novel RNA aptamer which binds specifically to Raf-1; a method for screening an RNA capable of binding specifically to the target protein of Ras which comprises selecting an RNA capable of binding to the target protein of Ras from a pool of RNAs having various base sequences; a method for regulating the transmission of a signal causing the proliferation or differentiation of cells by using the above-described nucleic acid; and medicinal compositions with the use of the same.
特許請求の範囲(英語) [claim1]
1. An RNA capable of being specifically bound to a Ras binding domain of Raf-1, wherein the RNA contains at least one sequence selected from sequence Nos. 1 to 8 or 25 to 28 of the Sequence Listing or a sequence of 81 to 99 bases obtainable by deletion of a base or bases from the 3'-terminus of sequence No. 25.
[claim2]
2. A nucleic acid having a complementary base sequence to the RNA defined in claim 1.
[claim3]
3. An agent for controlling cell signal transduction which agent is made of the RNA according to claim 1 or the nucleic acid according to claim 2.
[claim4]
4. A method of controlling cell signal transduction in vitro using the RNA according to claim 1 or a nucleic acid according to claim 2.
[claim5]
5. A pharmaceutical composition containing the RNA according to claim 1 or a nucleic acid according to claim 2.
[claim6]
6. Use of a pharmaceutical composition according to claim 5 in the manufacture of a medicament for use in the treatment of cancer or an inflammatory disease.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • YOKOYAMA SHIGEYUKI
  • HIRAO ICHIRO
  • SAKAMOTO KENSAKU
国際特許分類(IPC)
欧州特許分類/主・副
  • K61K038/00
  • M12N310/13
指定国 Contracting States: CH DE FR GB LI
参考情報 (研究プロジェクト等) ERATO YOKOYAMA CytoLogic AREA
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