TOP > 外国特許検索 > Catalyst and michael addition reaction process

Catalyst and michael addition reaction process

外国特許コード F110003953
整理番号 E07615WO
掲載日 2011年7月7日
出願国 欧州特許庁(EPO)
出願番号 09705661
公報番号 2258477
公報番号 2258477
出願日 平成21年1月28日(2009.1.28)
公報発行日 平成22年12月8日(2010.12.8)
公報発行日 平成27年3月25日(2015.3.25)
国際出願番号 JP2009051322
国際公開番号 WO2009096409
国際出願日 平成21年1月28日(2009.1.28)
国際公開日 平成21年8月6日(2009.8.6)
優先権データ
  • 2009JP051322 (2009.1.28) WO
  • 特願2008-015906 (2008.1.28) JP
発明の名称 (英語) Catalyst and michael addition reaction process
発明の概要(英語) Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time.
Specifically disclosed is a catalyst which is composed of MX 2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R 7 , R 8 , R 9 and R 10 each represents a substituted cyclic group or an unsubstituted cyclic group.]
特許請求の範囲(英語) [claim1]
1. A reaction method, comprising reacting a compound represented by the following general formula [II] with a compound represented by the following general formula [III] in the presence of a catalyst configured using MX 2 wherein M is Mg, Ca, Sr, or Ba, and X is OR **5 or an amide group, wherein R **5 is an alkyl group, and a compound represented by the following general formula [I]: (see diagramm) wherein R **7, R **8, R **9, and R **10 each represents a substituted cyclic group or a unsubstituted cyclic group and there are two cases for R **9 and R **10, i.e. the case that they form a ring and the case that they do not form a ring, (see diagramm)(see diagramm) wherein each of R **1, R **2, R **3, and R **4 is an arbitrary substituent and each of W **1, W **2, and W **3 is an electron-withdrawing group,
said reaction method being used for obtaining a compound represented by the following general formula [IV]: (see diagramm) wherein each of R **1, R **2, R **3, and R **4 is an arbitrary substituent, and each of W **1, W **2, and W **3 is an electron withdrawing group.
[claim2]
2. A reaction method according to claim 1, wherein an aromatic hydrocarbon solvent is used as a solvent of said reaction.
[claim3]
3. Use of a catalyst for catalyzing a reaction between a compound represented by the following general formula [II] and a compound represented by the following general formula [III] said catalyst configured using MX 2 wherein M is Mg, Ca, Sr, or Ba, and X is OR **5 or an amide group, wherein R **5 is an alkyl group, and a compound represented by the following general formula [I]: (see diagramm) wherein R **7, R **8, R **9, and R **10 each represents a substituted cyclic group or a unsubstituted cyclic group and there are two cases for R **9 and R **10, i.e. the case that they form a ring and the case that they do not form a ring, (see diagramm)(see diagramm) wherein each of R **1, R **2, R **3, and R **4 is an arbitrary substituent and each of W **1, W **2, and W **3 is an electron-withdrawing group.
[claim4]
4. A catalyst configured using MX 2 wherein M is Ca, Sr, or Ba , and X is OR **5 or an amide group, wherein R **5 is an alkyl group, and a compound represented by the following general formula [I]: (see diagramm) wherein R **7, R **8, R **9, and R **10 each represents a substituted cyclic group or a unsubstituted cyclic group and there are two cases for R **9 and R **10, i.e. the case that they form a ring and the case that they do not form a ring.
[claim5]
5. A catalyst according to claim 4, wherein said MX 2 is M(OR **5) 2 wherein M is Ca, Sr or Ba and R **5 is an alkyl group having a carbon number of 1 to 10.
[claim6]
6. A catalyst according to claim 4, wherein said MX 2 is Sr(OR **5) 2 and wherein R **5 is an alkyl group having a carbon number of 1 to 10.
[claim7]
7. A catalyst according to claim 4, wherein said X is hexamethyldisilazide.
[claim8]
8. A catalyst according to claim 4, wherein said cyclic group is an aromatic group.
[claim9]
9. A catalyst according to one of claim 4 to claim 8, wherein the compound represented by said general formula [I] and M of said compound MX 2 are coordinate-bonded to each other.
[claim10]
10. A reaction method according to claim 1, wherein said MX 2 is M(OR **5) 2 wherein M is Ca, Sr or Ba and R **5 is an alkyl group having a carbon number of 1 to 10.
[claim11]
11. A reaction method according to claim 1, wherein said MX 2 is Sr(OR **5) 2 and wherein R **5 is an alkyl group having a carbon number of 1 to 10.
[claim12]
12. A reaction method according to claim 1, wherein said X is hexamethyldisilazide.
[claim13]
13. A reaction method according to claim 1, wherein said cyclic group is an aromatic group.
[claim14]
14. A reaction method according to claim 1 or one of claims 10 to 13, wherein the compound represented by said general formula [I] and M of said compound MX 2 are coordinate-bonded to each other.
[claim15]
15. A reaction method according to claim 1, wherein each of said R **1, R **2, R **3, and R **4 is an H group or a hydrocarbon group.
[claim16]
16. A reaction method according to claim 1, wherein said electron-withdrawing group is an ester group or a carbonyl group.
[claim17]
17. A reaction method according to claim 1, wherein the compound represented by said general formula [II] is a dicarboxylate ester.
[claim18]
18. A reaction method according to claim 1, wherein the compound represented by said general formula [II] is a malonic ester.
[claim19]
19. A reaction method according to claim 1, wherein the compound represented by said general formula [III] is an enone.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KOBAYASHI SHU
  • AGOSTINHO MAGNO
  • SCHNEIDER UWE
  • YAMAGUCHI MIYUKI
国際特許分類(IPC)
指定国 Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
参考情報 (研究プロジェクト等) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
ライセンスをご希望の方、特許の内容に興味を持たれた方は、問合せボタンを押してください。

PAGE TOP

close
close
close
close
close
close