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Novel bisboron compound UPDATE

外国特許コード F110003962
整理番号 I018P007WO
掲載日 2011年7月7日
出願国 欧州特許庁(EPO)
出願番号 06833296
公報番号 1961756
公報番号 1961756
出願日 平成18年11月24日(2006.11.24)
公報発行日 平成20年8月27日(2008.8.27)
公報発行日 平成28年4月27日(2016.4.27)
国際出願番号 JP2006323492
国際公開番号 WO2007061074
国際出願日 平成18年11月24日(2006.11.24)
国際公開日 平成19年5月31日(2007.5.31)
優先権データ
  • 特願2005-340864 (2005.11.25) JP
  • 2006WO-JP323492 (2006.11.24) WO
発明の名称 (英語) Novel bisboron compound UPDATE
発明の概要(英語) (EP1961756)
A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R 1 and R 2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R 3 represents a hydrogen atom; -(CH 2 ) m -NR 4 R 5 ; -CO-(CH 2 ) m -NR 4 R 5 ; - COCH(NH 2 )R 6 ; -CHR 7 R 8 ; -CH 2 CH(NH 2 )-R 9 ; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic atomatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R 1 and R 2 , or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH 2 , S, SO 2 , CH 2 OCH 2 , OCH 2 , OCH 2 CH 2 OCH 2 , OCH 2 OCH 2 CH 2 and CH 2 OCH 2 CH 2 , or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.
特許請求の範囲(英語) [claim1]
1. A bisboron compound represented by the general formula (I): (see diagramm) wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R 1 and R 2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R 3 represents a hydrogen atom;
-(CH 2) m-NR 4R 5, wherein m represents an integer of 1 to 4, and R 4 and R 5 independently represent a hydrogen atom, or C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-C1-C4 alkylamino or phenyl group, or R 4 and R 5 are taken together with the nitrogen atom to which they are bonded to form a 5- or 6-membered cyclic ring;
-CO-(CH 2) m-NR 4R 5, wherein m, R 4 and R 5 are as defined above;
- COCH(NH 2)R 6, wherein R 6 represents an amino acid residue or -(CH 2) nNH 2, wherein n represents an integer of 1 to 3;
-CHR 7R 8, wherein R 7 and R 8 independently represent C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-(amino group-substituted or unsubstituted C1-C4 alkyl)amino or phenyl group, pyridyl, or phenyl substituted with C1-C3 alkoxy group;
-CH 2CH(NH 2)-R 9, wherein R 9 represents phenyl, or C1-C4 alkyl substituted with phenyl group;
quinolyl or isoquinolyl substituted with C1-C4 alkyl group;
or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R 1 and R 2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH 2, S, SO 2, CH 2OCH 2, OCH 2, OCH 2CH 2OCH 2, OCH 2OCH 2CH 2 and CH 2OCH 2CH 2, or a salt thereof,
provided that bis[2-(hydroxyphenylboryl)benzyl] ether, 1,4-bis(4-(hydroxyphenylboryl)phenoxy)butane, bis[4-(hydroxyphenylboryl)benzyl] ether, bis[2-[(2-aminoethoxy)phenylboryl]benzyl] ether, bis[4-((2-aminoethoxy)phenylboryl)benzyl] ether, [4-[(2-aminoethoxy)phenylboryl]benzyl] [2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl] ether, [2-[(2-aminoethoxy)phenylboryl]benzyl] [2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl] ether and salts thereof are excluded.
[claim2]
2. The bisboron compound or salt thereof according to claim 1, wherein the monocyclic aromatic group or polycyclic aromatic group is an aromatic group substituted or unsubstituted with at least one substituent selected from the group consisting of halogen, halogenated C1-C4 alkyl, cyano, hydroxy, sulfanyl, amino, nitro, mono- or di-C1-C4 alkylamino, carboxyl, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, C2-C4 alkenyl, C2-C4 alkynyl, cycloalkyl, cycloalkenyl, C1-C4 alkyl, C1-C4 alkylthio, C1-C4 alkoxy, aryl, amide and C1-C4 alkylamide.
[claim3]
3. The bisboron compound or salt thereof according to claim 1, wherein the heterocyclic group is a 5- to 15-membered heterocyclic group substituted or unsubstituted with at least one substituent selected from the group consisting of halogen, cyano, hydroxy, sulfanyl, amino, nitro, mono- or di-C1-C4 alkylamino, carboxyl, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, C2-C4 alkenyl, C2-C4 alkynyl, cycloalkyl, cycloalkenyl, C1-C4 alkyl, C1-C4 alkylthio, C1-C4 alkoxy, aryl, amide and C1-C4 alkylamide.
[claim4]
4. The bisboron compound or salt thereof according to claim 1, wherein the X is a group selected from the group consisting of the following groups. (see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)
[claim5]
5.
The bisboron compound or salt thereof according to claim 1, wherein the X is substituted or unsubstituted diphenyl ether, dibenzyl ether, phenyl benzyl ether, benzyl phenethyl ether, phenoxyethyl benzyl ether or diphenyl, having a meta-meta, ortho-ortho, para-para, meta-para, meta-ortho or ortho-para orientation.
[claim6]
6. The bisboron compound or salt thereof according to claim 5, wherein the X is diphenyl ether having any of meta-meta, ortho-ortho, para-para, ortho-para, ortho-meta and meta-para orientations.
[claim7]
7. The bisboron compound or salt thereof according to claim 6, wherein the X is diphenyl ether having a meta-meta, ortho-ortho or para-para orientation.
[claim8]
8. The bisboron compound or salt thereof according to claim 5, wherein the X is dibenzyl ether having any of meta-meta, ortho-para, ortho-meta and meta-para orientations.
[claim9]
9. The bisboron compound or salt thereof according to claim 8, wherein the X is dibenzyl ether having a meta-meta orientation.
[claim10]
10. The bisboron compound or salt thereof according to claim 5, wherein the X is benzyl phenethyl ether having any of meta-meta, ortho-ortho, ortho-meta and meta-para orientations.
[claim11]
11. The bisboron compound or salt thereof according to claim 10, wherein the X is benzyl phenethyl ether having a meta-meta or ortho-ortho orientation.
[claim12]
12. The bisboron compound or salt thereof according to claim 1, wherein the R 1 and R 2 are independently a substituted or unsubstituted phenyl or phenylene group.
[claim13]
13. The bisboron compound or salt thereof according to claim 1, wherein the R 3 is a hydrogen atom or a 2-aminoethyl group.
[claim14]
14. The bisboron compound or salt thereof according to claim 1, wherein the Y is an oxygen atom.
[claim15]
15. The bisboron compound according to claim 1, wherein the compound is selected from the group consisting of: bis(4,4'-(phenylhydroxyboryl)phenyl) ether;
bis(4,4'-(phenylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
bis(3,3'-(phenylhydroxyboryl)benzyl) ether;
bis(3,3'-(phenylaminoethoxyboryl)benzyl) ether;
bis(4-(4-trifluoromethylphenylhydroxyboryl)benzyl) ether;
bis(4-(1-naphthylhydroxyboryl)benzyl) ether;
bis(4-(fluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-methoxyphenylhydroxyboryl)benzyl) ether;
(3-(phenylhydroxyboryl)benzyl) (4-(phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)benzyl) (3-(phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)benzyl) (4-(phenylhydroxyboryl)benzyl) ether;
(3-(phenylaminoethoxyboryl)benzyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
bis(3-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
(2-(phenylaminoethoxyboryl)benzyl) (3-(phenylaminoethoxyboryl)benzyl) ether;
2-(phenylaminoethoxyboryl)benzyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
bis(3-(4-fluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-fluorophenylaminoethoxyboryl)benzyl) ether;
bis(4-(4-chloro-3-methyl-phenylhydroxyboryl)benzyl) ether;
bis(4-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) ether;
bis(3-(3',4'-methylenedioxy-phenylhydroxyboryl)benzyl) ether;
(3-(3-chloro-4-methylphenylhydroxyboryl)benzyl) (4-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
(3-(3',4',5'-trifluorophenylhydroxyboryl)benzyl) (4-(3',4',5'-trifluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-methoxyphenylaminoethoxyboryl)benzyl) ether;
(3-(4-chloro-3-methylphenylhydroxyboryl)benzyl) (2-(4-chloro-3-methylphenylhydroxyboryl)benzyl) ether;
bis(3-(4-cyanophenylhydroxyboryl)benzyl) ether;
bis(3-(2'-thiophenylhydroxyboryl)benzyl) ether;
bis(3-(1'-naphthylhydroxyboryl)benzyl) ether;
bis(3-(2'-thiophenylhydroxyboryl)benzyl) ether;
bis(4-(2-methoxy-5-fluorophenylhydroxyboryl)benzyl) ether;
bis(4-(2-methoxy-5-fluorophenylaminoethoxyboryl)benzyl) ether;
(3-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) (2-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) ether;
bis(4-(3,4-difluorophenylhydroxyboryl)benzyl) ether;
bis(4-(3,4-difluorophenylaminoethoxyboryl)benzyl) ether;
(3-(3',4',5'-trifluorophenylaminoethoxyboryl)benzyl) (4-(3',4',5'-trifluorophenylaminoethoxyboryl)benzyl) ether;
5,5'-(phenylhydroxyboryl)-2,2'-dithiophene;
5,5'-(phenylaminoethoxyboryl)-2,2'-dithiophene;
3,5-di(phenylaminoethoxyboryl)toluene;
2,5-di(phenylhydroxyboryl)toluene;
2,2'-di(phenylhydroxyboryl)-1,1'-binaphthyl;
2,2'-di(phenylaminoethoxyboryl)-1,1'-binaphthyl;
bis(4-(4-methylphenylhydroxyboryl)benzyl) ether;
bis(4-(4-methylphenylaminoethoxyboryl)benzyl) ether;
4,4'-(4-methylphenylaminoethoxyboryl)diphenyl;
4,4'-(4-methylphenylhydroxyboryl)diphenyl ether;
4,4'-(4-methylphenylaminoethoxyboryl)diphenyl ether;
4,4'-bis(3-chloro-4-methyl-phenylaminoethoxyboryl)phenyl ether;
(2-(phenylhydroxyboryl)phenethyl) ((2-phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)phenethyl) ((2-phenylaminoethoxyboryl)benzyl) ether;
(4-phenylhydroxyborylphenyl) (4'-phenylhydroxyborylbenzyl) ether;
(4-phenylaminoethoxyborylphenyl) (4'-phenylaminoethoxyborylbenzyl) ether;
(4-(2-thiopheneaminoethoxyboryl)phenoxyethyl) (4'-(2-thiopheneaminoethoxyboryl)benzyl) ether;
(4-trifluoromethylphenylhydroxyborylphenyl) (4'-trifluoromethylphenylhydroxyborylbenzyl) ether;
(4-trifluoromethylphenylaminoethoxyborylphenyl) (4'-trifluoromethylphenylaminoethoxyborylbenzyl) ether;
9,10-bis-(trifluoromethylphenylhydroxyboryl)anthracene;
9,10-bis-(trifluoromethylphenylaminoethoxyboryl)anthracene;
bis(3-(1-naphthylaminoethoxyboryl)benzyl) ether;
4,5-di(phenylhydroxyboryl)-2,7-di-t-butyl-9,9-dimethylxanthrene;
4,5-di(phenylaminoethoxyboryl)-2,7-di-t-butyl-9,9-dimethylxanthrene;
(4-(phenylhydroxyboryl)phenoxyethyl) (4-(phenylhydroxyboryl)benzyl) ether;
(4-(phenylaminoethoxyboryl)phenoxyethyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
6,6'-(phenylhydroxyboryl)-2,2'-dipyridyl;
6,6'-(phenylaminoethoxyboryl)-2,2'-dipyridyl;
bis(2,5-(phenylhydroxyboryl)furan;
bis(2,5-(phenylaminoethoxyboryl)furan;
bis(4,4'-(phenyl-N,N-dimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-N-methylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-glycineboryl)phenyl) ether;
bis(4,4'-(phenyl-glutamineboryl)phenyl) ether;
bis(4,4'-(phenyl-cysteineboryl)phenyl) ether;
bis(4,4'-(phenyl-asparagineboryl)phenyl) ether;
(4-(phenyl-N-methylaminoethylboryl)phenyl) (4'-(hydroxymethylphenyl-N-methylaminoethylboryl)phenyl) ether;
(4-(phenyl-N,N-dimethylaminoethylboryl)phenyl)(4'-(hydroxymethylphenyl-N,N-dimethylaminoethylboryl)phenyl) ether;
(4-(phenyl-glutamic acid boryl)phenyl) (4'-(hydroxymethylphenyl-glutamic acid boryl)phenyl) ether;
(4-(phenyl-glutamineboryl)phenyl) (4'-(hydroxymethylphenyl-glutamineboryl)phenyl) ether;
bis(4,4'-(phenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-aminoethyl-aminoethoxyboryl)phenyl) ether;
(4-(phenyl-cysteineboryl)phenyl) (4'-(hydroxymethylphenyl-cysteineboryl)phenyl) ether;
bis(4,4'-(phenoxyphenyl-aminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-N-aminoethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-methylaminoethoxyboryl)benzyl) ether;
(4'-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)-4-phenyl (4'-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)benzyl ether;
(4'-trifluoromethylphenyl-N-methylaminoethoxyboryl)-4-phenyl (4'-trifluoromethylphenyl-N-methylaminoethoxyboryl)-4-benzyl ether;
bis(3,3'-(phenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-asparagineboryl)benzyl) ether;
bis(3,3'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(phenyl-lysineboryl)benzyl) ether;
bis(4,4'-(p-methoxymethyl-phenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N-aminoethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-2-piperidylmethyloxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-asparagineboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-aminoethoxyboryl)benzyl) ether;
(4-phenyl-N-methylaminoethoxyborylphenyl) 4'-(N-methylaminoethoxyborylbenzyl) ether;
(4-phenyl-N,N-dimethylaminoethoxyborylphenyl) 4'-(N,N-dimethylaminoethoxyborylbenzyl) ether;
(4-phenyl-2-pyridylmethoxyborylphenyl) (4'-phenyl-2-pyridylmethoxyborylbenzyl) ether;
4-(phenyl-p-methoxyphenyl-2-pyridylmethoxyboryl)-phenyl 4'-(p-methoxyphenyl-2-pyridylmethoxyboryl)benzyl ether;
bis(4,4'-(phenyl-3-piperidyloxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-aminothioethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-amino-1-phenylethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-ornithineboryl)phenyl) ether;
bis(4,4'-(phenyl-2,3-diaminopropionic acid boryl)phenyl) ether;
bis(4,4'-(phenyl-lysineboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyrrolidinemethoxyboryl)phenyl) ether;
bis(4,4'-(naphthylhydroxyboryl)phenyl) ether;
bis(4,4'-(tolylhydroxyboryl)phenyl) ether;
bis(4,4'-(naphthyl-aminoethoxyboryl)phenyl) ether;
bis(4,4'-(naphthyldimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(naphthyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(naphthylglutamineboryl)phenyl) ether;
bis(4,4'-(naphthyl-2,4-diaminopropionic acid boryl)phenyl) ether;
bis(4,4'-(tolyldimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(tolylpiperazylethoxyboryl)phenyl) ether;
bis(4,4'-(tolylglutamineboryl)phenyl) ether;
bis(4,4'-(tolyllysineboryl)phenyl) ether;
bis(4,4'-(phenyl-2-amino-1-phenylethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-pyrrolidinemethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(4,4'-(phenyl-butylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-phenylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-benzylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-methylpiperidine-methoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-1-piperidylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-pyrrolidinomethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-phenyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-piperazylmethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-dimethylaminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-piperidylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-pyridylmethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-amino-1-phenylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-N-methylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-N-aminoethyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-glutamineboryl)benzyl) ether;
bis(3,3'-(phenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(3,3'-(phenyl-N-butylaminoethylboryl)benzyl) ether;
bis(3,3'-(phenyl-asparagineboryl)benzyl) ether;
bis(3,3'-(phenyl-lysineboryl)benzyl) ether;
bis(3,3'-(phenyl-ornithineboryl)benzyl) ether;
bis(4,4"-(phenyl-2-methyl-8-quinolinooxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-benzyl-2-amino-ethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-benzyl-2-amino-ethoxyboryl)phenyl) ether;
bis(3,3'-(phenyl-2-benzyl-2-amino-ethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-phenyl-2-amino-ethoxyboryl)benzyl) ether;
and salts thereof.
[claim16]
16. A composition for controlling the intracellular calcium concentration, characterized in that the composition comprises the bisboron compound or salt thereof according to any one of claims 1 to 15 as an active ingredient.
[claim17]
17. The composition according to claim 16, which is used for prevention, alleviation or treatment of a disease caused by an increase in the intracellular calcium concentration.
[claim18]
18. The composition according to claim 16, which inhibits release of endogenous calcium and/or entry of capacitative calcium.
[claim19]
19. The composition according to claim 17, wherein the disease is ischemic heart or brain disease, cardiac hypertrophy, renal disease, hypertension, cerebral vasospasm, pancreatitis, asthma, immunodeficiency, allergic disease, or Alzheimer's disease.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • MIKOSHIBA KATSUHIKO
  • OZAKI SHOICHIRO
  • SUZUKI AKINOBU
  • NAKAMURA TAKESHI
国際特許分類(IPC)
欧州特許分類/主・副
  • C07F005/02C
指定国 (EP1961756)
Contracting States: DE FR GB
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