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Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome

外国特許コード F110004019
整理番号 K02303WO
掲載日 2011年7月8日
出願国 欧州特許庁(EPO)
出願番号 08855467
公報番号 2221065
公報番号 2221065
出願日 平成20年11月21日(2008.11.21)
公報発行日 平成22年8月25日(2010.8.25)
公報発行日 平成28年12月28日(2016.12.28)
国際出願番号 JP2008071212
国際公開番号 WO2009069546
国際出願日 平成20年11月21日(2008.11.21)
国際公開日 平成21年6月4日(2009.6.4)
優先権データ
  • 特願2007-305122 (2007.11.26) JP
  • 2008WO-JP71212 (2008.11.21) WO
発明の名称 (英語) Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
発明の概要(英語) (EP2221065)
The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others.
The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.
特許請求の範囲(英語) [claim1]
1. An agent for use in the therapy or prophylaxis of metabolic syndrome wherein the agent comprises a DNA described in any one of (a) to (c) below, encoding receptor activity modifying 2 (RAMP2) protein, or a polypeptide encoded by the DNA; (a) a DNA having a base sequence described in SEQ.
ID. No. 1; (b) a DNA having a base sequence which is capable of hybridizing under stringent conditions with the base sequence described in SEQ.
ID. No. 1; (c) a DNA consisting of a base sequence having a homology of 90% or more with the base sequence described in SEQ.
ID. No. 1.
[claim2]
2. An in vitro test method for testing the contraction of metabolic syndrome or testing the propensity to contract metabolic syndrome comprising: an extraction step of extracting DNA from a cell from a test subject; an amplification step of carrying out a polymerase chain reaction using a primer which is capable of selectively amplifying a DNA consisting of the base sequence described in SEQ.
ID. No. 3, with the extracted DNA as a template; a determination step of determining a base sequence of the amplified DNA; a comparison step of comparing the determined base sequence with the base sequence described in SEQ.
ID. No. 3; and, wherein differences are noted, it is judged whether or not the symptoms relating to metabolic syndrome are improved or their worsening is suppressed, when the DNA amplified in the amplification step is introduced into a cell, tissue, or organ where the RAMP2 has been mutated to remove its function or knocked out.
[claim3]
3. Use of SEQ.
ID. No. 3, or a primer amplifying SEQ ID No. 3, in an in vitro method of drug screening for metabolic syndrome.
[claim4]
4. Use of an antibody that binds selectively to SEQ.
ID. No. 2 in an in vitro method of drug screening for metabolic syndrome.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • SHINDO TAKAYUKI
国際特許分類(IPC)
欧州特許分類/主・副
  • A01K067/027M2
  • C07K014/705
  • C12N015/85A
  • G01N033/68F
  • K01K217/07B1
  • K01K217/15
  • K01K217/20B
  • K01K227/10M
  • K01K267/03K4
  • K01K267/03K
  • K61K038/00
  • K61K048/00
  • M12Q001/68M6
  • S01N500/00
  • S01N800/04
指定国 (EP2221065)
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
参考情報 (研究プロジェクト等) PRESTO Metabolism and Cellular Function AREA
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