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Molecule-responsive gel fine particles, process for production of the same and use thereof 新技術説明会

外国特許コード F110004022
整理番号 K02801WO
掲載日 2011年7月8日
出願国 欧州特許庁(EPO)
出願番号 08752151
公報番号 2154166
公報番号 2154166
出願日 平成20年4月25日(2008.4.25)
公報発行日 平成22年2月17日(2010.2.17)
公報発行日 平成26年2月19日(2014.2.19)
国際出願番号 JP2008058117
国際公開番号 WO2008139902
国際出願日 平成20年4月25日(2008.4.25)
国際公開日 平成20年11月20日(2008.11.20)
優先権データ
  • 2008JP058117 (2008.4.25) WO
  • 特願2007-122459 (2007.5.7) JP
発明の名称 (英語) Molecule-responsive gel fine particles, process for production of the same and use thereof 新技術説明会
発明の概要(英語) The invention provides molecule-responsive gel particles which change in size in response to specific molecules and a method of production of the same.
A polymer gel particle with a crosslinked structure has fixed thereto a plurality of clathrate compound-forming host molecules two or more of the plurality of host molecules clathrate different atomic groups in a target molecule so that the two or more host molecules and the target molecule can form a crosslink in the molecule-responsive gel particle.(see diagramm)
特許請求の範囲(英語) [claim1]
1. A molecule-responsive gel particle changing in volume in response to a target molecule, comprising: a polymer gel particle; and a plurality of clathrate compound-forming host molecules fixed to the polymer gel particle the polymer gel particle being obtained by emulsion polymerization of a monomer having a single polymerizable C=C double bond and a hydrophilic crosslinking monomer having two or more polymerizable C=C double bonds and an alkylene glycol chain of general formula (1)

-(RO) n- (1)

where R is an alkylene group of a carbon number 1 to 6 and may or may not vary from one RO repeat unit to another, and n is an integer from 2 to 20.
[claim2]
2. The molecule-responsive gel particle as set forth in claim 1, wherein n is an integer from 2 to 13.
[claim3]
3. The molecule-responsive gel particle as set forth in claim 1 or 2, wherein two or more of the plurality of host molecules clathrate different atomic groups in the target molecule so that the two or more host molecules and the target molecule form a crosslink in the molecule-responsive gel particle.
[claim4]
4. The molecule-responsive gel particle as set forth in any one of claims 1 to 3, wherein the molecule-responsive gel particle changes in volume in the presence of target molecules each containing two or more atomic groups which can be clathrated by the plurality of host molecules.
[claim5]
5. The molecule-responsive gel particle as set forth in any one of claims 1 to 4, wherein the molecule-responsive gel particle is a hydrogel.
[claim6]
6. The molecule-responsive gel particle as set forth in any one of claims 1 to 5, wherein the plurality of host molecules is at least one or more types of molecules selected from the group consisting of cyclodextrin, crown compounds, cyclophane, azacyclophane, calixarene, and derivatives thereof.
[claim7]
7. The molecule-responsive gel particle as set forth in any one of claims 1 to 6, wherein letting a net amount of the monomer having a single polymerizable C=C double bond and the hydrophilic crosslinking monomer be 100 mol%, the crosslinking monomer is used within a range of 0.1 to 50 mol%.
[claim8]
8. The molecule-responsive gel particle as set forth in any one of claims 1 to 7, wherein: the monomer having a single polymerizable C=C double bond is a (meth)acrylate monomer, a vinyl ether monomer, vinyl acetate, or styrenes; and the crosslinking monomer is polyalkylene glycol di(meth)acrylate, polyalkylene glycol tri(meth)acrylate, polyalkylene glycol divinyl ether, or polyalkylene glycol trivinyl ether.
[claim9]
9. The molecule-responsive gel particle as set forth in any one of claims 1 to 8, wherein the plurality of host molecules is used in 0.1 to 40 mol% with respect to anet amount of the plurality of host molecules and all the feedstock monomers.
[claim10]
10. The molecule-responsive gel particle as set forth in any one of claims 1 to 9, wherein the molecule-responsive gel particle has an average diameter of 10 nm to 50 micron m.
[claim11]
11. A dry product obtained by drying the molecule-responsive gel particles as set forth in any one of claims 1 to 10.
[claim12]
12. A method of producing molecule-responsive gel particles, comprising: the reactive-functional-group-introducing step of introducing reactive functional groups to at least one type of host molecules; and the polymerization step of emulsion polymerizing a polymer-gel-fine-particle forming monomer having a single polymerizable C=C double bond in the presence of a hydrophilic crosslinking monomer and the reactive-functional-group-introduced host molecules obtained in the reactive-functional-group-introducing step so as to obtain molecule-responsive gel particles, the hydrophilic crosslinking monomer having two or more polymerizable C=C double bonds and an alkylene glycol chain of general formula (1)

-(RO) n- (1)

where R is an alkylene group of a carbon number 1 to 6 and may or may not vary from one RO repeat unit to another, and n is an integer from 2 to 20, preferably from 2 to 13.
[claim13]
13. The method as set forth in claim 12, wherein the host molecules are at least one or more types of molecules selected from the group consisting of cyclodextrin, crown compounds, cyclophane, calixarene, and derivatives thereof.
[claim14]
14. The method as set forth in either one of claims 12 and 13, wherein letting a net amount of the monomer having a single polymerizable C=C double bond and the hydrophilic crosslinking monomer be 100 mol%the crosslinking monomer is used within a range of 0.1 to 50 mol%.
[claim15]
15. A target molecule detection kit, comprising the molecule-responsive gel particles as set forth in any one of claims 1 to 10.
[claim16]
16. A target-substance-adsorption/removal material, comprising the molecule-responsive gel particles as set forth in any one of claims 1 to 10.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • MIYATA TAKASHI
  • URAGAMI TADASHI
国際特許分類(IPC)
欧州特許分類/主・副
  • B01J013/00D6
  • B01J020/26
  • B01J020/28B4
  • B01J020/28D32
  • C08B037/00M2B
  • C08B037/00M2B2
  • C08F290/10
指定国 Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
参考情報 (研究プロジェクト等) PRESTO Structures and control of interfaces AREA
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