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Multipurpose linker compounds and ligands and process for producing the same 実績あり

外国特許コード F110004105
整理番号 P028P02EP
掲載日 2011年7月11日
出願国 欧州特許庁(EPO)
出願番号 03794076
公報番号 1548016
公報番号 1548016
出願日 平成15年8月6日(2003.8.6)
公報発行日 平成17年6月29日(2005.6.29)
公報発行日 平成27年5月20日(2015.5.20)
国際出願番号 JP2003009973
国際公開番号 WO2004022565
国際出願日 平成15年8月6日(2003.8.6)
国際公開日 平成16年3月18日(2004.3.18)
優先権データ
  • 2003JP009973 (2003.8.6) WO
  • 特願2002-263414 (2002.9.9) JP
  • 特願2003-190637 (2003.7.2) JP
発明の名称 (英語) Multipurpose linker compounds and ligands and process for producing the same 実績あり
発明の概要(英語) A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof.
With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility.
Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.
特許請求の範囲(英語) [claim1]
1. A linker compound of
a structure represented by following general formula (1), where Y has a structure represented by O or NH, and (see diagramm) X has a structure represented by following general formula (2), wherein m **1, m **2, n **1, n **2, p **1, p **2, p **3, and p **4 are all represented by 2. (see diagramm)
[claim2]
2. A ligand of a structure represented by following general formula (3), where m **1, m **2, n **1, n **2, p **1, p **2, p **3, and p **4 are all represented by 2. (see diagramm) where Y has a structure represented by O or NH, and R **1, R **2, R **3, and R **4 independently has a structure represented by (see diagramm) and R **6, R **7, R **8, R **9, and R **10 have a structure selected from the group consisting of (see diagramm)
[claim3]
3. A ligand of a structure represented by following general formula (4), where Y has a structure represented by O or NH, and m **1, m **2, n **1, n **2, p **1, p **2, p **3, and p **4 are all represented by 2. (see diagramm)
[claim4]
4. A method for producing the linker compound of Claim 1, comprising the steps of: carrying out a condensation reaction between a biotin compound and an amine compound including four branched chains each having an aromatic amino group end protected by a protecting group; and deprotecting the protecting group at the aromatic amino group end.
[claim5]
5. A producing method of a ligand, comprising the step of carrying out a reductive amination reaction by using the linker compound of claim 1 or 2 and a sugar molecule.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • SUDA YASUO
  • ARANO AKIO
  • HAYASHI HIDEKI
  • KUSUMOTO SHOICHI
  • SOBEL MICHAEL
国際特許分類(IPC)
指定国 Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
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