TOP > 外国特許検索 > STABLE ISOTOPE-LABELED AMINO ACID AND METHOD FOR INCORPORATING THE SAME INTO TARGET PROTEIN, NMR METHOD FOR THE STRUCTURAL ANALYSIS OF PROTEIN AND METHOD FOR PRODUCING REGIO-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID

STABLE ISOTOPE-LABELED AMINO ACID AND METHOD FOR INCORPORATING THE SAME INTO TARGET PROTEIN, NMR METHOD FOR THE STRUCTURAL ANALYSIS OF PROTEIN AND METHOD FOR PRODUCING REGIO-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID 実績あり

外国特許コード F110004242
整理番号 A021-16CA
掲載日 2011年7月13日
出願国 カナダ
出願番号 2471105
公報番号 2471105
公報番号 2471105
出願日 平成14年12月19日(2002.12.19)
公報発行日 平成15年7月3日(2003.7.3)
公報発行日 平成22年1月12日(2010.1.12)
優先権データ
  • 特願2001-386823 (2001.12.19) JP
  • 特願2002-022446 (2002.1.30) JP
発明の名称 (英語) STABLE ISOTOPE-LABELED AMINO ACID AND METHOD FOR INCORPORATING THE SAME INTO TARGET PROTEIN, NMR METHOD FOR THE STRUCTURAL ANALYSIS OF PROTEIN AND METHOD FOR PRODUCING REGIO-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID 実績あり
発明の概要(英語)

The present invention provides a stable isotope-labeled amino acid which is at least one of amino acids constituting a protein and which has at least one of the following labeling patterns: (a) hydrogen atoms except at least one hydrogen atom in one or more methylene groups are deuterated, (b) hydrogen atoms in one of prochiral gem-methyl groups are completely deuterated, (c) hydrogen atoms in prochiral methyl groups are partially deuterated, and (d) all hydrogen atoms except one of them in methyl group are deuterated and hydrogen atoms in the aromatic ring are partially deuterated.

With the stable isotope-labeled amino acid, the deuteration of protein can be attained without damaging the NMR sensitivity of remaining hydrogen nucleus and, in addition, the rapid, accurate analysis of NMR spectrum of a high-molecular protein which is beyond the limitation in the prior art and the determination of the stereo-structure can be performed at the same time.

  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KAINOSHO, MASATSUNE,
  • TERAUCHI, TSUTOMU
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Genetic Programming AREA
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