RAT MODEL WITH THE ONSET OF PROSTATE CANCER
To provide a rat model with the onset of prostate cancer in which the prosta te cancer including an invasive cancer can be developed and can be bred for generation s stably. A rat model with the onset of prostate cancer which can develop prostate cancer including invasive cancer and can be bred for generations stably is established by: ligating an SV40 large T antigen gene onto the downstream of rat probasin ge ne promoter
the resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat
after the introduction, the fertilized egg is transplant ed into a recipient rat
a transgenic rat obtained from the recipient rat is then mate d with a wild- type Sprague-Dawley rat
the transgenic offspring rats thus obtained are similarly can be bred for generations thereafter
and transgenic rats developing prostate cancer are selected through histopathological observation of the prostate.