TOP > 外国特許検索 > NOVEL ADAPTOR PROTEIN THAT BINDS TO MAMMALIAN TOLL-LIKE RECEPTOR 3, AND GENE THEREOF

NOVEL ADAPTOR PROTEIN THAT BINDS TO MAMMALIAN TOLL-LIKE RECEPTOR 3, AND GENE THEREOF

外国特許コード F110004354
整理番号 A211-02CA
掲載日 2011年7月14日
出願国 カナダ
出願番号 2507716
公報番号 2507716
公報番号 2507716
出願日 平成15年11月20日(2003.11.20)
公報発行日 平成16年6月17日(2004.6.17)
公報発行日 平成23年8月16日(2011.8.16)
優先権データ
  • 特願2002-349015 (2002.11.29) JP
発明の名称 (英語) NOVEL ADAPTOR PROTEIN THAT BINDS TO MAMMALIAN TOLL-LIKE RECEPTOR 3, AND GENE THEREOF
発明の概要(英語)

A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is effective for prevention/ treatment of viral infectious disease such as hepatitis B, hepatitis C, and the like, treatment of tumors, and the other purposes. Novel adaptor protein TICAM-1, which has an amino acid sequence set forth in SEQ ID NO: 2 or NO: 4, has the property of specifically binding to the mammalian Toll-like receptor 3 and a property of inducing type I interferon production.

A mutant of the adaptor protein TICAM-1 has similar properties, provided that it has TIR domain (an amino acid sequence ranging from 394-position to 532-position in the amino acid sequence set forth in SEQ ID NO: 2 or an amino acid sequence ranging 396-position to 534-position in the amino acid sequence set forth in SEQ ID NO: 4. The gene is a gene encoding the adaptor protein TICAM-1.

  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • SEYA, TSUKASA,
  • MATSUMOTO, MISAKO,
  • OSHIUMI, HIROYUKI
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA
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