TOP > 外国特許検索 > CELL-SPECIFIC HERPES SIMPLEX VIRUS EXPRESSION/REPLICATION VECTOR COMPRISING ICP4 AND HUMAN CALPONIN GENE PROMOTER

CELL-SPECIFIC HERPES SIMPLEX VIRUS EXPRESSION/REPLICATION VECTOR COMPRISING ICP4 AND HUMAN CALPONIN GENE PROMOTER

外国特許コード F110004381
整理番号 B08-01CA
掲載日 2011年7月14日
出願国 カナダ
出願番号 2471822
公報番号 2471822
公報番号 2471822
出願日 平成14年12月26日(2002.12.26)
公報発行日 平成15年7月17日(2003.7.17)
公報発行日 平成24年7月24日(2012.7.24)
優先権データ
  • 特願2001-402102 (2001.12.28) JP
  • 特願2002-255395 (2002.8.30) JP
発明の名称 (英語) CELL-SPECIFIC HERPES SIMPLEX VIRUS EXPRESSION/REPLICATION VECTOR COMPRISING ICP4 AND HUMAN CALPONIN GENE PROMOTER
発明の概要(英語)

The present invention is to provide a method wherein a cell-specific expression/replication vector that express and replicate a gene specifically in specific cells such as malignant tumors and the like and does not injure normal cells, particularly a vector that can suppress the expression/replication at a desired period after the expression/replication is constructed, f or the use in therapies for such as malignant tumors and the like, and treatment is conducted by introducing the vector to a particular living cell such as malignant tumor and the like for expression. A cell-specific expression/replication vector that does not act to adult normal cells is constructed by: a transcriptional initiation regulatory region of human calponin gene that is expressed in smooth muscle cell specifically is obtained

said region is linked upstream of the replication-related gene of virus such as ICP4 and the like

a DNA that encodes proteins such as suppressive factor for tumor angiogenesis or apoptosis-related factors and the like is linked via IRES to said replication-related gene of the virus

and thyimidine kinase gene in an intact state is integrated into a viral DNA. This vector thus constructed is infected and introduced to malignant tumor cells, and malignant tumor cells are selectively disrupted.

  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • YAMAMURA, HISAKO,
  • TAKAHASHI, KATSUHITO
国際特許分類(IPC)
参考情報 (研究プロジェクト等) SORST Selected in Fiscal 2000
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