CELL-SPECIFIC REPLICATION-COMPETENT VECTOR
The present invention provides a method for constructing a vector which expresses and replicates a gene specifically to particular cells
a DNA having a gene expression regulatory activity used for its construction
and further, a treatment method comprising the steps of introducing said vector into particular living tissues or cells such as malignant tumors and the like, and said vector expressing and replicating a gene. A cell-specific replication-competent vector which does not act to normal cells in an adult body is constructed by obtaining a transcriptional initiation regulatory region of human calponin gene which is expressed specifically in cells
by linking it upstream of a viral replication-related gene
and by integrating it into a virus DNA.
Said constructed cell-specific replication-competent vector is introduced into malignant tumor cells to selectively injure tumor cells or proliferating smooth muscle cells of tumor neovascular.