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Linker Compound, Ligand, and Producing Method Thereof 実績あり

外国特許コード F110004899
整理番号 P028P01KR
掲載日 2011年7月22日
出願国 大韓民国
出願番号 20057003969
公報番号 20050057270
公報番号 100710808
出願日 平成17年3月8日(2005.3.8)
公報発行日 平成17年6月16日(2005.6.16)
公報発行日 平成19年4月23日(2007.4.23)
国際出願番号 JP2003011417
国際公開番号 WO2004022583
国際出願日 平成17年3月8日(2005.3.8)
国際公開日 平成16年3月18日(2004.3.18)
優先権データ
  • 特願2002-263412 (2002.9.9) JP
  • 特願2003-190568 (2003.7.2) JP
発明の名称 (英語) Linker Compound, Ligand, and Producing Method Thereof 実績あり
発明の概要(英語) A linker compound having a structure represented by the following general formula (1): (1) wherein n is an integer of 1 to 6, and wherein X has a structure being a multi-branched structure moiety comprising three or four hydrocarbon chains which has an aromatic amino group at the terminal thereof and may contain a carbon- nitrogen bond in the main chain thereof; and a ligand which comprises the linker compound and a saccharide introduced therein.
特許請求の範囲(英語) [claim1]
1. General formula (1)


(Wherein n is an integer between 1 and 6 and below) is represented in the structure with the

Hydrocarbon induced chain above with aromatic amino group at the end have a carbon 1 nitrogen coupling in the main chain, chain 3 or 4 strands, comprising many linker has a structure in the branch structure to feature 1 compounds
[claim2]
2. the above is general formula (2)


(The m1, m2, m3 , independently, an integer between 1 and 6) to have claims to have the structure represented the range stated in paragraph 1 of the linker compounds.
[claim3]
3. above equation (2) in m1, m2, m3 , linker compounds range No. 2 written claims to be all 2 to feature.
[claim4]
4. the above is general formula (3)


(The m-4, m5m6m7, p p 2 is independent, an integer between 1 and 6 and below) claims features and has a structure that is represented by the range stated in paragraph 1 of the linker compounds.
[claim5]
5. these general formula (3) in the m-4, m-5, m6, πι7 is all 2, and ρ ρ 2 is one in which range the 2 paragraphs stated claim to special payment linker compounds 1.
[claim6]
6. in request scope (1) or paragraph (5) or paragraph linker of the described resource that introduces the sugar molecules on the aromatic amino compound to feature Gunn de.
[claim7]
7. these sugar molecules are Monosaccharides, oligosaccharides, and polysaccharides at least one or from ligand for the invoice will be selected to feature the scope paragraph 6.
[claim8]
8. General formula (4)



(The m ',zm,3m, n are independent, an integer between 1 and 6) ligands to features and has a structure that is represented in. '
[claim9]
9. Above equation (4) in which all 2 m1, m2, m3 , range the 8 sections stated claim to be one that characterized the ligand is n.

1 0. Equation (5)


(5)

(The m-4, m5, 6,7m, n and p p 2 are separate, the more than 6 less than or equal) to features and has a structure that is represented in Riga pounds.

1 1. Above equation (5) in the NUM4, ni5, m-6, m-7 in all 2 is, where n is 1, and p 1and p 2 is a ligand for the claim that neither one to feature the range 0 stated in paragraph 1.

1 2. Condensation reactions with amine compounds protected by protection based on chiotato acid and aromatic amino group at the end, having had branched chains of 3 or 4 strands and line u States (plastic model)

Please include the above aromatic amino group at the end of edge protection for deprotection with state space segmentation and that linker compounds and features manufacturing method.

1 3. Manufacturing method of characteristics to either request scope (1) or paragraph (5) paragraph (1) linker in compounds 1 and sugar using a reductive amination reaction to Ligand.

1 4. Method of introduction of sugar sugar molecules arranged on the surface of the substrate. In any of the range of claims paragraph 6 and paragraph 1 described ligands, including introduction of advanced payment to be in contact with including solutions and surface with the metal substrate, glucose molecules.

1 5. Rigan de support you support on any of the range of claims paragraph 6 and paragraph 1 paragraph (1) with surface metal mentioned rigan de peg to feature material.

1 6. For surface Plasmon covariance, determination of range of claims is used as a sensor chip, 1/5-ligand carriers listed.

1 7. AFI two claims used in the column for matography take mouth range 1 section 5 of the ligand carriers listed.
  • 出願人(英語)
  • KAGOSHIMA UNIVERSITY
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • SUDA YASUO
  • ARANO AKIO
  • KUSUMOTO SHOICHI
  • SOBEL MICHAEL
国際特許分類(IPC)
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