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Versatile Linker Compound, Ligand and Producing Method Thereof 実績あり

外国特許コード F110004900
整理番号 P028P02KR
掲載日 2011年7月22日
出願国 大韓民国
出願番号 20057004021
公報番号 20050065540
公報番号 100761881
出願日 平成17年3月9日(2005.3.9)
公報発行日 平成17年6月29日(2005.6.29)
公報発行日 平成19年10月4日(2007.10.4)
国際出願番号 JP2003009973
国際公開番号 WO2004022565
国際出願日 平成17年3月9日(2005.3.9)
国際公開日 平成16年3月18日(2004.3.18)
優先権データ
  • 特願2002-263414 (2002.9.9) JP
  • 特願2003-190637 (2003.7.2) JP
発明の名称 (英語) Versatile Linker Compound, Ligand and Producing Method Thereof 実績あり
発明の概要(英語) A multipurpose linker compound having a structure represented by the following general formula (1): (1) wherein Y has a structure represented by O or NH.
In the above formula, X has a multibranched site structure involving 4 hydrocarbon derivative chains each having an aromatic amino group at the end and optionally having a carbon-nitrogen bond in the main chain.
This multipurpose linker compound makes it possible to two-dimensionally align saccharide molecules at a high reproducibility on the surface of a support for protein analysis.
A ligand in which saccharide molecules have been introduced into the above- described multipurpose linker compound.
特許請求の範囲(英語) [claim1]

General formula (1)



(The Y has a structure that is represented by the O or N H) is represented in the structure with the

Above is the range of usage type resources poorly compounds characteristic to have structure in the diverse, comprising 4-chain hydrocarbon induced chain may have main-chain carbon 1 nitrogen combined with aromatic amino group at the end.
[claim2]
2. Above is a general expression (2)


H2N

(The m1, m2, n n p p 2, p p 4 , independently, an integer between 1 and 6) has a structure that is represented by the features shall demand the range stated in paragraph 1 range of applications-linker compounds.
[claim3]
3. above equation (2) in m1, m2, n n p p p 3 and p 4 the range No. 2 written claims to have the structure are all represented at the 2 range of application types linker compounds;
[claim4]
4. in request scope (1) or paragraph (3) or paragraph that described diverse usage type linker compounds of aromatic amino group, introduced to sugar molecules that characterized ligand.
[claim5]
5. these sugar molecules is a ligand for the claim to Monosaccharides, oligosaccharides, polysaccharides of that range (4).
[claim6]
6. General equation (3)



(R1, R2, R3and R4 are independent, the Y has a structure that is represented by the O or NH

H-or with structure that is represented in the


The R6, R-7, R-8, R9, R10
HO ― or in the dual structure is represented
Structure is chosen from the Group)

(M1, m2, n 1, n 2, P P 2, p 3and p 4 is independent of the expression in the

An integer between 1 and 6) has a structure that is represented by a special payment shall be ligand.
[claim7]
7. General formula (4)


(The Y has a structure that is represented by the O or NH, m1, m2, n l, n _p p p 3and p 4 are independent, is an integer between 1 and 6) to features and has a structure that is represented by ligand.

And the condensation reaction of biochinn compounds with aminn compounds with 4 chain branched chain protected by protection based on aromatic amino at the end of step 8.

Include these aromatic amino group at the end of edge protection for deprotection steps and have to feature diverse applications-linker compounds manufacturing methods.
[claim8]
9. method of manufacture feature to any request-scope (1) or paragraph (3) of paragraph (1) 1 compounds described diverse usage type linker and sugar molecules, using reductive amination reaction to Ligand.

1 0. Introduction of sugar molecules arranged on the surface of the substrate sugar molecules in

Introduction of sugar molecules feature to be in contact with the substrate surface with a solution containing ligand described in paragraph (1) any of the scope of paragraph 4 or paragraph (7) fixed sutoreputoabijinn or abijinn.

1 1. That let immobilized on the surface of the substrate through any of the scope of paragraph 4 or paragraph (7) paragraph (1) in the combined posting areas or iminobiochinn sites and Streptavidin or abijinn ligand in piochinnaabijinn that characterized ligand carriers.

1 2. Billing features to Streptavidin or avidin immobilized substrate above the range 1 paragraph 1 of the stated ligand carriers.

1 3. Claims can be used for the measurement of surface plasmon resonance sensor chip range 1 paragraph 1 or paragraph 2 of ligand carriers.

1 4. AFI two claims used in the column for matography take mouth range 1 paragraph 1 or paragraph 2 of ligand carriers.

1 5. To detect the interaction of sugar sugar molecules immobilized on the support surface sensor chip using a surface plasmon resonance measurement method

Sugar molecules differ from the Terminal structure was introduced, which, using at least two Seng sat map

Includes 2 1 1 glucose molecule immobilized on the supporting surface, a sensor chip and above 1 glucose molecule differ in leaf structure of sugar molecules on the support surface immobilized the sensor chip and sensor chip in at least two,

Measurement method of surface plastic carbons when contacted resonance to measure the difference in detection results obtained with 1 sensor chip and detection results obtained with two Seng sack (plastic model).

1 6. Claims to features in the above sensor chip in request scope (1) or paragraph (3) linker compounds of the same structure in sugar molecules will be immobilized range 1 section 5 of the measuring method of surface plasmon resonance.

1 7. Stands for number of sugar molecules will be immobilized in the above sensacitzp to feature requests ranges, 1 paragraph 5 or paragraph 6 of surface plasmon resonance measurements.
  • 出願人(英語)
  • KAGOSHIMA UNIVERSITY
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • SUDA YASUO
  • ARANO AKIO
  • HAYASHI HIDEKI
  • KUSUMOTO SHOICHI
  • SOBEL MICHAEL
国際特許分類(IPC)
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