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Linker compound, ligand complex and process for producing them 実績あり

外国特許コード F110004965
整理番号 P028P07WO
掲載日 2011年7月28日
出願国 大韓民国
出願番号 20067018117
公報番号 20070018876
公報番号 100877644
出願日 平成18年9月5日(2006.9.5)
公報発行日 平成19年2月14日(2007.2.14)
公報発行日 平成21年1月9日(2009.1.9)
国際出願番号 JP2005001726
国際公開番号 WO2005075453
国際出願日 平成18年9月5日(2006.9.5)
国際公開日 平成17年8月18日(2005.8.18)
発明の名称 (英語) Linker compound, ligand complex and process for producing them 実績あり
発明の概要(英語) A novel linker compound that minimizes any nonspecific hydrophobic interactions and is capable of easily regulating the length to disulfide group subjected to metal bond to thereby enable efficient formation of metal-sulfur bond; a novel ligand complex or ligand carrying substance; and a process for producing them.
There is provided a linker compound comprising the structure of the general formula: (1) (wherein each of a, b, d and e independently is an integer of 0 to 6).
The above X at a molecular end has an aromatic amino group and at its main chain has a structure of multi-branched structural site composed of 3 or more hydrocarbon-derived chains optionally having carbon-nitrogen bonds.
The ligand complex consists of the above linker compound having a sugar molecule introduced therein.
© KIPO & WIPO 2007
特許請求の範囲(英語) [claim1]

[1] general formula (1)

[Of 1]


(The a, b, d, and e are independent, an integer between 0 and 6 and below) is represented in the structure with the

Above have aromatic amino-terminal with main chain carbon-nitrogen bonds have V, even, hydrocarbon induced chain over 3 chain, comprising hyperbranched structure site structure bei, are features to linker compounds 1.

Equation (2)

[Of 2]



(Wherein n is an integer between 1 and 6 and below) is represented in the structure with the

Above have aromatic amino-terminal with main chain carbon-nitrogen combined with V, even, hydrocarbon induced chain over 3 chain, comprising hyperbranched structure site structure bei, who claim 1 to feature mentioned linker compounds 1.

Above is a general expression (3)

[Of 3]



(The m1, m2, m-3, m-4, p1, p2 , independently, an integer between 1 and 6) at table to have the structure to claim 1 or 2 mentioned linker compounds 1. Above is a general expression (4)

[Of 4]



(The q1, q2, q-3, r1, r, r, t1, t2, t3, u, u,3 is, each independent, 0 over 6 or less of integer) structure is represented in the has features claims section 1 or 2 to stated of linker compounds 1.

[5] claim 1, in either paragraph (1) of 4 to feature to be introduced on the linker 1 compounds of aromatic amino sugar molecule ligand complexes.

[6] general formula (5)

[Of 5]


(The m1,,3m,4m, n, p1, p2 , independently, an integer between 1 and 6. R ' is hydrogen (H) or R. ) Is represented in the structure with the

Expression is above R (6-1) a! ヽ expression and (6 ― 6)

[Of 6]



(6-1) (6-2)



(6-4) (6-5)

Power options the oligosaccharides derived from compounds that that characterized ligand complexes, [7] general formula (7)

[Of 7]


(The a, b, d, e, q1, q, q,
t, t, u, u, u are independent, an integer between 0 and 6. However, the b 0 t1, t2 and t3 is always in 0 t1, t2 and t3 0 0, b is not. In addition, R ' is hydrogen (H) or R. ) Is represented by the structure equipped with the

Ceremony above R (6-1) a! ヽ and expression (6 ― 6)

[Of 8]




(6-3)


From selected oligosaccharides derived from compounds that feature-ligand complex.

[8] claim 1 wherein a!, and 4 of paragraph (1) to linker compound 1 in manufacturing methods in culture outside with acid and aromatic amino group at the end have been protected by protection based on branched chains of 3 or more and Amini spoonful of condensed reaction step and

Linker features to contain these aromatic amino group at the end of edge protection for deprotection step 1 compounds for manufacturing.

Do Huan Yuan amino alkylation [9] claim 1 and (1) one or more of the 4 mentioned linker compounds 1 and sugar molecules, using characteristic ligand complex production methods.

These sugar molecules is a general expression (8)


Represented at the to sulfated oligosaccharide with Palin part 2 sugar structure that features shall they claim 9, stated ligand composite and method for production.

These sugar molecules that group (9)

[Of 10]



Claim 9 features to use at least one of the power options are oligosaccharides, stated Li Gund complex production methods.

Introduction of sugar molecules to array [12] sugar molecules on the surface of the substrate in the

Introduction of sugar molecules to be contacted and claim 5 or paragraph (1) or 7-ligand complexes in solution and surface with the metal substrate.

By peg on [13] claim 5 or paragraph (1) or 7 stated ligand complex surface with a metal support that characterized ligand carriers.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • SUDA YASUO
  • ARANO AKIO
  • KUSUMOTO SHOICHI
  • SOBEL MICHAEL
  • WAKAO MASAHIRO
国際特許分類(IPC)
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