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Hapten compound and antibody

外国特許コード F110004980
整理番号 RX03P55WO
掲載日 2011年8月2日
出願国 欧州特許庁(EPO)
出願番号 06811315
公報番号 1988094
公報番号 1988094
出願日 平成18年10月5日(2006.10.5)
公報発行日 平成20年11月5日(2008.11.5)
公報発行日 平成26年6月11日(2014.6.11)
国際出願番号 JP2006319977
国際公開番号 WO2007097065
国際出願日 平成18年10月5日(2006.10.5)
国際公開日 平成19年8月30日(2007.8.30)
優先権データ
  • 2006JP319977 (2006.10.5) WO
  • 特願2006-046950 (2006.2.23) JP
発明の名称 (英語) Hapten compound and antibody
発明の概要(英語) The present invention is a compound having a structure represented by the following formula (1): , and an antibody to BSH obtained by using the compound as a hapten and using a complex of the hapten and a high-molecular compound as an antigen.
By using the present invention, it becomes possible to provide a hapten compound for preparing an antibody recognizing BSH highly sensitively and highly selectively, an antibody to BSH, as well as a kit for measuring BSH and an immunological measuring method having high sensitivity and excellent in quantitative property using the antibody.
特許請求の範囲(英語) [claim1]
1. A compound having a structure represented by the following formula (1): (see diagramm)
[claim2]
2. A monoclonal antibody to mercaptoundecahydrododecaborate (BSH) obtained by using the compound as defined in claim 1 as a hapten and using a complex of the hapten and a high-molecular compound as an antigen.
[claim3]
3. A hybridoma producing a monoclonal antibody as defined in claim 2.
[claim4]
4. The hybridoma according to claim 3, wherein the hybridoma is BSF-2 (accession number FERM AP-20805).
[claim5]
5. A monoclonal antibody produced by the hybridoma of claim 4.
[claim6]
6. A kit for measuring mercaptoundecahydrododecaborate (BSH), comprising a monoclonal antibody as defined in claim 2 or 5.
[claim7]
7. A method of measuring mercaptoundecahydrododecaborate (BSH), comprising using a monoclonal antibody as defined in claim 2 or 5.
[claim8]
8. A method of measuring mercaptoundecahydrododecaborate (BSH), comprising using a kit as defined in claim 6.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • OSAKA PREFECTURE UNIVERSITY
  • STELLA CHEMIFA
  • 発明者(英語)
  • KIRIHATA MITSUNORI
  • ASANO TOMOYUKI
  • UEHARA KOHKI
国際特許分類(IPC)
欧州特許分類/主・副
  • C07F005/02D
  • C07K016/44
  • G01N033/53F
  • G01N033/84
  • G01N033/94
指定国 Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
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