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STABLE ISOTOPE-LABELED AROMATIC AMINO ACIDS, METHOD FOR INCORPORATING THE SAME IN TARGET PROTEIN AND METHOD FOR NMR-STRUCTURAL ANALYSIS OF PROTEINS 実績あり

外国特許コード F110005002
整理番号 A202-01WO
掲載日 2011年8月8日
出願国 カナダ
出願番号 2544305
公報番号 2544305
公報番号 2544305
出願日 平成16年11月1日(2004.11.1)
公報発行日 平成17年5月12日(2005.5.12)
公報発行日 平成23年7月12日(2011.7.12)
優先権データ
  • 特願2003-373304 (2003.10.31) JP
発明の名称 (英語) STABLE ISOTOPE-LABELED AROMATIC AMINO ACIDS, METHOD FOR INCORPORATING THE SAME IN TARGET PROTEIN AND METHOD FOR NMR-STRUCTURAL ANALYSIS OF PROTEINS 実績あり
発明の概要(英語)

The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, 2 to 4 carbon atoms of the remaining 5 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked, and a stable isotope-labeled tyrosine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, the carbon atom bonded to the hydroxyl group (OH group) of the phenyl group is 12C or 13C, 2 to 4 carbon atoms of the remaining 4 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked.

The stable isotope-labeled amino acid permits the elimination of such a conventional problem concerning the complexity of the NMR signals ascribed to aromatic rings, the complexity being a principal cause of making the NMR analysis difficult, encountered when using the conventional uniformly labeled amino acid residue. Moreover, the isotope-labeled amino acid likewise permits the substantial improvement of the sensitivity thereof to the NMR spectroscopic analysis.

  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KAINOSHO, MASATSUNE,
  • TERAUCHI, TSUTOMU
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Understanding the Brain (Mechanisms of Brain) AREA
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