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Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide 実績あり

外国特許コード F110005034
整理番号 A031-33US
掲載日 2011年8月18日
出願国 アメリカ合衆国
出願番号 34338801
公報番号 20030149999
公報番号 7371921
出願日 平成13年7月31日(2001.7.31)
公報発行日 平成15年8月7日(2003.8.7)
公報発行日 平成20年5月13日(2008.5.13)
国際出願番号 JP2001006555
国際公開番号 WO2002009508
国際出願日 平成13年7月31日(2001.7.31)
国際公開日 平成14年2月7日(2002.2.7)
優先権データ
  • 特願2000-232451 (2000.7.31) JP
  • 2001WO-JP06555 (2001.7.31) WO
発明の名称 (英語) Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide 実績あり
発明の概要(英語) (US7371921)
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model.
A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated.
With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.
特許請求の範囲(英語) [claim1]
1. A transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein macrophage cells isolated from the transgenic mouse are unresponsive to MALP-2.
[claim2]
2. A macrophage cell isolated from a transgenic mouse whose genome comprises a homozygous disruption of the TLR-6 gene, said TLR-6 gene encoding a polypeptide that recognizes a MALP-2 mycoplasma-derived lipoprotein/lipopeptide, wherein the macrophage cell is unresponsive to MALP-2.
  • 発明者/出願人(英語)
  • AKIRA SHIZUO
  • TAKEUCHI OSAMU
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 800/18
  • 435/325
  • 435/340
  • 435/355
  • 800/3
参考情報 (研究プロジェクト等) CREST Host Defense Mechanism AREA
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