TOP > 外国特許検索 > Process for producing porous composite materials

Process for producing porous composite materials

外国特許コード F110005186
整理番号 A122-29US
掲載日 2011年8月25日
出願国 アメリカ合衆国
出願番号 49230002
公報番号 20050004242
公報番号 7163965
出願日 平成14年5月1日(2002.5.1)
公報発行日 平成17年1月6日(2005.1.6)
公報発行日 平成19年1月16日(2007.1.16)
国際出願番号 JP2002004355
国際公開番号 WO2003092759
国際出願日 平成14年5月1日(2002.5.1)
国際公開日 平成15年11月13日(2003.11.13)
優先権データ
  • 2002WO-JP04355 (2002.5.1) WO
発明の名称 (英語) Process for producing porous composite materials
発明の概要(英語) (US7163965)
This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant.
The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability.
Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
特許請求の範囲(英語) [claim1]
1. A process for producing porous and composite materials comprising steps of: cooling a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized, to gelate the gelatin;
freezing it;
and then lyophilizing the resultant.
[claim2]
2. A process for producing porous and composite materials comprising a step of introducing surface crosslinking between collagens to the porous and composite materials obtained by the process according to claim 1.
[claim3]
3. The process according to claim 2, wherein the step of introducing surface crosslinking is carried out by immersing the porous and composite materials in a solution containing a crosslinking agent.
[claim4]
4. The process according to any one of claims 1 to 3 comprising a step of adding a crosslinking agent to gelatinized collagen to introduce internal crosslinking between collagens.
[claim5]
5. The process according to any one of claims 1 to 3, wherein the calcium salt is hydroxyapatite.
[claim6]
6. A process for producing porous and composite materials comprising the following steps of:
1) gelatinizing at least a part of the collagen constituting a complex containing hydroxyapatite and collagen;
2) introducing internal crosslinking between collagens with the addition of a crosslinking agent to the complex;3) obtaining porous and composite materials by cooling the complex to gelate the gelatin, freezing it, and then lyophilizing the resultant;
and
4) introducing surface crosslinking between collagens by immersing the porous and composite materials in a solution containing a crosslinking agent.
[claim7]
7. The process according to claim 2 or 3, wherein internal and/or surface crosslinking between collagens is introduced using glutaraldehyde as a crosslinking agent.
[claim8]
8. The process according to any one of claims 1 to 3, wherein surface crosslinking between collagens is introduced by immersing the porous and composite materials in a solution containing a crosslinking agent comprising ethanol as a solvent.
[claim9]
9. The process according to any one of claims 1 to 3, wherein the resulting porous and composite materials have porosities of 80% or higher.
[claim10]
10. The process according to any one of claims 1 to 3 using a complex comprising the c-axis of hydroxyapatite being oriented along collagen fibers.
[claim11]
11. Porous and composite materials having porosities of 80% or higher, which are produced by the method according to any one of claims 1 to 3.
[claim12]
12. Implants of the porous and composite materials according to claim 11.
  • 発明者/出願人(英語)
  • SOTOME SHINICHI
  • UEMURA TOSHIMASA
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TATEISHI TETSUYA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
国際特許分類(IPC)
米国特許分類/主・副
  • 521/64
  • 434/423
  • 521/61
  • 521/92
  • 521/102
  • 623/11.11
  • 623/16.11
  • 623/23.51
  • 623/23.61
参考情報 (研究プロジェクト等) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
ライセンスをご希望の方、特許の内容に興味を持たれた方は、問合せボタンを押してください。

PAGE TOP

close
close
close
close
close
close