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Acetyllysine-recognizing monoclonal antibody and process for producing the same 実績あり

外国特許コード F110005192
整理番号 A131-07US
掲載日 2011年8月25日
出願国 アメリカ合衆国
出願番号 47147502
公報番号 20040198959
公報番号 7204984
出願日 平成14年3月13日(2002.3.13)
公報発行日 平成16年10月7日(2004.10.7)
公報発行日 平成19年4月17日(2007.4.17)
国際出願番号 JP2002002330
国際公開番号 WO2002074962
国際出願日 平成14年3月13日(2002.3.13)
国際公開日 平成14年9月26日(2002.9.26)
優先権データ
  • 特願2001-074263 (2001.3.15) JP
  • 2002WO-JP02330 (2002.3.13) WO
発明の名称 (英語) Acetyllysine-recognizing monoclonal antibody and process for producing the same 実績あり
発明の概要(英語) (US7204984)
Anti-acetyllysine monoclonal antibody capable of recognizing Nepsilon-acetyllysine regardless of the types of the adjacent amino acids.
Namely, a monoclonal antibody having a light chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:1 and a variable region having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and a heavy chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:3 and a variable region having the amino acid sequence represented by SEQ ID NO:4 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and being capable of recognizing Nepsilon-acetyllysine in a protein regardless of the types of the adjacent amino acids, i.e., being capable of accepting adjacent amino acids over a broad range; and a process for producing this monoclonal antibody characterized by using a chemically acetylated protein as an antigen.
特許請求の範囲(英語) [claim1]
1. A monoclonal antibody recognizing an Nepsilon -acetyllysine, comprising:
(1) a light chain comprising a constant region having an amino acid sequence represented by SEQ ID NO. 1 and a variable region having an amino acid sequence selected from the group consisting of SEQ ID NO. 2, SEQ ID NO. 5, SEQ ID NO. 6 and SEQ ID NO. 7;
and(2) a heavy chain comprising a constant region having an amino acid sequence represented by SEQ ID NO. 3 and a variable region having an amino acid sequence selected from the group consisting of SEQ ID NO. 4, SEQ ID NO. 8, SEQ ID NO. 9 and SEQ ID NO. 10.
[claim2]
2. The monoclonal antibody according to claim 1, wherein the monoclonal antibody is a mouse monoclonal antibody.
[claim3]
3. A monoclonal antibody recognizing an Nepsilon -acetyllysine, comprising:
(1) a light chain comprising a constant region having an amino acid sequence represented by SEQ ID NO. 1 and a variable region having an amino acid sequence represented SEQ ID NO. 7;
and(2) a heavy chain comprising a constant region having an amino acid sequence represented by SEQ ID NO. 3 and a variable region having an amino acid sequence represented by SEQ ID NO. 10.
  • 発明者/出願人(英語)
  • KOMATSU YASUHIKO
  • YOSHIDA MINORU
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 424/133.1
  • 424/141.1
  • 530/388.1
参考情報 (研究プロジェクト等) CREST Structure and Function of Genomes AREA
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