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Numb protein expression inhibitors by Musashi 実績あり

外国特許コード F110005212
整理番号 A192-04US
掲載日 2011年8月26日
出願国 アメリカ合衆国
出願番号 34331101
公報番号 20040054140
公報番号 7264793
出願日 平成13年11月22日(2001.11.22)
公報発行日 平成16年3月18日(2004.3.18)
公報発行日 平成19年9月4日(2007.9.4)
国際出願番号 JP2001010231
国際公開番号 WO2002099102
国際出願日 平成13年11月22日(2001.11.22)
国際公開日 平成14年12月12日(2002.12.12)
優先権データ
  • 特願2001-164412 (2001.5.31) JP
  • 2001WO-JP10231 (2001.11.22) WO
発明の名称 (英語) Numb protein expression inhibitors by Musashi 実績あり
発明の概要(英語) (US7264793)
An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.
By the present invention, a new function of Musashi protein has been elucidated.
Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
特許請求の範囲(英語) [claim1]
1. A method for potentiating neural stem cell proliferating activity, which comprises administering an effective amount of mammalian Musashi 1 protein to a mammalian subject by injection.
[claim2]
2. A method according to claim 1, wherein said injection is to the tissue or cells of said mammalian subject.
[claim3]
3. The method of claim 1, wherein said mammalian Musashi 1 protein is isolated from cells in which they are naturally expressed.
[claim4]
4. The method of claim 1, wherein said mammalian Musashi 1 protein is prepared by DNA recombination technology comprising transfected cells with an expression vector containing the cloned gene encoding for said mammalian Musashi 1 protein.
[claim5]
5. The method of claim 1, wherein said mammalian Musashi 1 protein is a mouse Musashi 1 protein.
[claim6]
6. The method of claim 1, wherein said mammalian Musashi 1 protein is isolated from mammalian CNS stem cells.
[claim7]
7. The method of claim 1, wherein said effective amount ranges from 0.1 mu g to 10 mg per day in terms of the weight of the Musashi 1 protein.
[claim8]
8. The method of claim 1, wherein said neural stem cell proliferation is by inhibiting expression of Numb protein .
[claim9]
9. The method of claim 1, wherein said neural stem cell proliferation is by potentiating Notch signaling.
  • 発明者/出願人(英語)
  • IMAI TAKAO
  • TOKUNAGA AKINORI
  • YOSHIDA TETSU
  • MIKOSHIBA KATSUHIKO
  • NAKAFUKU MASATO
  • OKANO HIDEYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 424/9.1
  • 435/69.1
  • 435/320.1
  • 435/325
  • 435/455
  • 514/8.3
  • 514/17.7
  • 514/21.2
参考情報 (研究プロジェクト等) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
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