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Method of constructing spinal injury model monkey and utilization thereof 新技術説明会 実績あり

外国特許コード F110005213
整理番号 A192-13US
掲載日 2011年8月26日
出願国 アメリカ合衆国
出願番号 49699302
公報番号 20050186545
公報番号 7753054
出願日 平成14年11月26日(2002.11.26)
公報発行日 平成17年8月25日(2005.8.25)
公報発行日 平成22年7月13日(2010.7.13)
国際出願番号 JP2002012308
国際公開番号 WO2003045137
国際出願日 平成14年11月26日(2002.11.26)
国際公開日 平成15年6月5日(2003.6.5)
優先権データ
  • 特願2001-364563 (2001.11.29) JP
  • 2002WO-JP12308 (2002.11.26) WO
発明の名称 (英語) Method of constructing spinal injury model monkey and utilization thereof 新技術説明会 実績あり
発明の概要(英語) (US7753054)
A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.
According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury.
This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury.
Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
特許請求の範囲(英語) [claim1]
1. A method for creating a monkey model of cervical spinal cord injury, comprising exposing the dura mater of the cervical cord of a monkey and applying a load onto the exposed dura mater of the cervical cord region, wherein the load weighs 15 to 25 g and is applied by being caused to fall from 20 to 60 mm above the dura mater, wherein the monkey model exhibits a protracted disorder in motor function compared to a monkey to which the load has not been applied.
[claim2]
2. The method according to claim 1, wherein the monkey in which spinal cord injury has been created has a motor function disorder which is comparable to that of human spinal cord injury.
[claim3]
3. The method according to claim 1, wherein said dura mater is exposed by excising any one of the C3 to C7 cervical vertebrae.
[claim4]
4. The method according to claim 1, wherein the protracted disorder of motor function is at least one member selected from the group consisting of limb movement, turning movement, seated posture, standing, jumping, extension of forelimbs, reaching with forelimb, grasping an object with forelimb, climbing, holding with limb, and combinations thereof.
  • 発明者/出願人(英語)
  • OKANO HIDEYUKI
  • TOYAMA YOSHIAKI
  • NAKAMURA MASAYA
  • NOMURA TATSUJI
  • TANIOKA YOSHIKUNI
  • ANDO KIYOSHI
  • KANEMURA YONEHIRO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • KEIO UNIVERSITY
国際特許分類(IPC)
米国特許分類/主・副
  • 128/898
参考情報 (研究プロジェクト等) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
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