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Adaptor protein that binds to mammalian toll-like receptor 3, and gene thereof

外国特許コード F110005217
整理番号 A211-02US
掲載日 2011年8月26日
出願国 アメリカ合衆国
出願番号 53680203
公報番号 20060134128
公報番号 7582437
出願日 平成15年11月20日(2003.11.20)
公報発行日 平成18年6月22日(2006.6.22)
公報発行日 平成21年9月1日(2009.9.1)
国際出願番号 JP2003014854
国際公開番号 WO2004050868
国際出願日 平成15年11月20日(2003.11.20)
国際公開日 平成16年6月17日(2004.6.17)
優先権データ
  • 特願2002-349015 (2002.11.29) JP
  • 2003WO-JP14854 (2003.11.20) WO
発明の名称 (英語) Adaptor protein that binds to mammalian toll-like receptor 3, and gene thereof
発明の概要(英語) (US7582437)
A novel adaptor protein and its gene are provided.
The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is effective for prevention/treatment of viral infectious disease such as hepatitis B, hepatitis C, and the like, treatment of tumors, and the other purposes.
Novel adaptor protein TICAM-1, which has an amino acid sequence set forth in SEQ ID NO: 2 or NO: 4, has the property of specifically binding to the mammalian Toll-like receptor 3 and a property of inducing type I interferon production.
A mutant of the adaptor protein TICAM-1 has similar properties, provided that it has TIR domain (an amino acid sequence ranging from 394-position to 532-position in the amino acid sequence set forth in SEQ ID NO: 2 or an amino acid sequence ranging 396-position to 534-position in the amino acid sequence set forth in SEQ ID NO: 4.
The gene is a gene encoding the adaptor protein TICAM-1.
特許請求の範囲(英語) [claim1]
1. A method of screening for a compound that inhibits the binding between a human Toll-like receptor 3 and a protein comprised of the amino acid sequence of SEQ ID NO:2 or the amino acid sequence from position 394 to position 532 of SEQ ID NO:2, the method comprising contacting a candidate compound with a cell transfected with a DNA molecule encoding said protein, wherein said cell naturally expresses human Toll-like receptor 3; and
measuring whether said compound inhibits the binding between said protein and human Toll-like receptor 3.
[claim2]
2. An isolated protein comprised of the amino acid sequence from position 394 to position 532 of SEQ ID NO: 2, wherein proline at position 434 is replaced with histidine, wherein said protein specifically binds to a human Toll-like receptor 3 but fails to induce interferon beta production.
[claim3]
3. An isolated DNA molecule encoding the protein as set forth in claim 2.
[claim4]
4. A recombinant expression vector having a DNA molecule as set forth in claim 3.
[claim5]
5. An isolated host cell transformed with a recombinant expression vector as set forth in claim 4.
  • 発明者/出願人(英語)
  • SEYA TSUKASA
  • MATSUMOTO MISAKO
  • OSHIUMI HIROYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 435/7.1
  • 435/7.21
  • 435/69.1
  • 435/320.1
  • 435/471
  • 530/351
  • 536/23.5
参考情報 (研究プロジェクト等) CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA
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