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Method of determining absolute configuration of chiral compound

外国特許コード F110005276
整理番号 E04703US
掲載日 2011年8月29日
出願国 アメリカ合衆国
出願番号 14865200
公報番号 20030008406
公報番号 7354771
出願日 平成12年12月4日(2000.12.4)
公報発行日 平成15年1月9日(2003.1.9)
公報発行日 平成20年4月8日(2008.4.8)
国際出願番号 JP2000008559
国際公開番号 WO2001040774
国際出願日 平成12年12月4日(2000.12.4)
国際公開日 平成13年6月7日(2001.6.7)
優先権データ
  • 特願1999-345538 (1999.12.3) JP
  • 2000WO-JP08559 (2000.12.4) WO
発明の名称 (英語) Method of determining absolute configuration of chiral compound
発明の概要(英語) (US7354771)
The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site, and (ii) analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon based on the sign of the Cotton effect.
The chiral compound has an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group.
特許請求の範囲(英語) [claim1]
1. A method for determining the absolute configuration of a chiral compound which comprises: coordinating the chiral compound to a metalloporphyrin represented by the following formula (I):
{mu {{5,5'- (ethane-1, 2-diyl) bis [2, 3, 7, 8, 12, 13, 17, 18-octaethyl-21H, 23H-porphyrinato](4-)}-kappa N21, -kappa N22, -kappa N23, -kappa N24, -kappa N21', -kappa N22', -kappa N23', -kappa N24', }}dizinc,
the chiral compound having an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group;
and analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon of the chiral compound based on the sign of the Cotton effect, wherein when the first Cotton effect is positive, the absolute configuration of the chiral compound is (S), and when the first Cotton effect is negative, the absolute configuration of the chiral compound is (R).
[claim2]
2. The method according to claim 1 wherein the chiral compound is 1) a primary amine, 2) a secondary amine, 3) a primary diamine, 4) a secondary diamine, 5) a monoalcohal, or 6) an aminoalcohol.
  • 発明者/出願人(英語)
  • INOUE YOSHIHISA
  • BOROVKOV VICTOR
  • LINTULUOTO JUHA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 436/164
  • 435/280
  • 502/182
  • 502/226
  • 514/188
  • 540/604
  • 544/4
  • 544/47
  • 546/25
  • 549/230
  • 549/260
参考情報 (研究プロジェクト等) ERATO INOUE Photo-chirogenesis AREA
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