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Replication vector showing cell-specific expression

外国特許コード F110005344
整理番号 K01002US
掲載日 2011年8月31日
出願国 アメリカ合衆国
出願番号 47779702
公報番号 20040197308
公報番号 7696332
出願日 平成14年4月30日(2002.4.30)
公報発行日 平成16年10月7日(2004.10.7)
公報発行日 平成22年4月13日(2010.4.13)
国際出願番号 JP2002004334
国際公開番号 WO2002092816
国際出願日 平成14年4月30日(2002.4.30)
国際公開日 平成14年11月21日(2002.11.21)
優先権データ
  • 特願2001-143999 (2001.5.14) JP
  • 2002WO-JP04334 (2002.4.30) WO
発明の名称 (英語) Replication vector showing cell-specific expression
発明の概要(英語) (US7696332)
The present invention provides a cell-specific replication-competent vector system, which does not target normal cells.
The vector system is constructed by linking a transcriptional initiation regulatory promoter region upstream of a viral replication-related gene that integrates the linked region into a viral DNA vector.
The constructed vector, when introduced into malignant tumor cells, selectively injures only tumor cells or proliferating smooth muscle cells of tumor neovascular tissue due to the selective expression of the regulatory promoter region upstream of a viral replication-related gene.
In particular, the present invention relates to a transcriptional initiation regulatory region of the human calponin gene that can selectively express in tumor cells or proliferating smooth muscle cells of tumor neovascular tissue.
The present invention also relates to methods of constructing the cell-specific replication-competent vector system and to treatment methods using the vector system by introducing the vector system into particular living tissues or cells such as malignant tumors and the like.
特許請求の範囲(英語) [claim1]
1. An isolated DNA consisting of the nucleotide sequence of Seq.
ID No. 1 or the complementary sequence thereof.
[claim2]
2. An isolated DNA consisting of the nucleotide sequence of Seq.
ID No. 2 or the complementary sequence thereof.
[claim3]
3. An isolated DNA consisting of the nucleotide sequence of Seq.
ID No. 3 or the complementary sequence thereof.
[claim4]
4. An isolated DNA comprising a nucleotide sequence consisting of a truncated calponin promoter set forth by SEQ ID NO: 1 or 2 and an heterologous enhancer operably linked upstream of the truncated calponin promoter, wherein the isolated DNA does not comprise the full-length calponin promoter.
[claim5]
5. The isolated DNA according to claim 4, wherein the enhancer is a 4F2 enhancer.
  • 発明者/出願人(英語)
  • TAKAHASHI KATSUHITO
  • YAMAMURA HISAKO
  • MIYATAKE SHIN-ICHI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 536/23.1
  • 536/24.1
参考情報 (研究プロジェクト等) PRESTO Unit Process and Combined Circuit AREA
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