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Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome

外国特許コード F110005400
整理番号 K02303WO
掲載日 2011年9月5日
出願国 アメリカ合衆国
出願番号 73486408
公報番号 20110027187
公報番号 8858915
出願日 平成20年11月21日(2008.11.21)
公報発行日 平成23年2月3日(2011.2.3)
公報発行日 平成26年10月14日(2014.10.14)
国際出願番号 JP2008071212
国際公開番号 WO2009069546
国際出願日 平成20年11月21日(2008.11.21)
国際公開日 平成21年6月4日(2009.6.4)
優先権データ
  • 特願2007-305122 (2007.11.26) JP
  • 2008JP071212 (2008.11.21) WO
発明の名称 (英語) Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
発明の概要(英語) The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others.
The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.
特許請求の範囲(英語) [claim1]
1. A screening method for a therapeutic drug for metabolic syndrome, comprising: a step of bringing into contact a test substance and a polypeptide having the amino acid sequence identified as SEQ ID NO:2, and which binds to calcitonin receptor-like receptor (CRLR); and
a step of detecting binding between the polypeptide and the test substance.
  • 発明者/出願人(英語)
  • SHINDO TAKAYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 424/9.2
  • 435/6.18
参考情報 (研究プロジェクト等) PRESTO Metabolism and Cellular Function AREA
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