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REPLICATION VECTOR SHOWING CELL-SPECIFIC EXPRESSION

外国特許コード F040000564
整理番号 F040000564
掲載日 2005年4月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2002JP004334
国際公開番号 WO 2002/092816
国際出願日 平成14年4月30日(2002.4.30)
国際公開日 平成14年11月21日(2002.11.21)
優先権データ
  • 特願2001-143999 (2001.5.14) JP
発明の名称 (英語) REPLICATION VECTOR SHOWING CELL-SPECIFIC EXPRESSION
発明の概要(英語) A vector showing expression and replication of a gene specifically in specific cells is constructed. A DNA having a gene expression controlling activity to be used in the construction is provided. Further, a therapeutic method wherein the above vector is transferred into a specific tissue such as malignant tumor or cellsin vivo and allowed to express and replicate the gene is provided. The transcriptional initiation regulatory domain of human calponin gene, which is specifically expressed in cells, is obtained and ligated to the upstream of a virus replication-associated gene. Then the ligated product is integrated into a virus DNA to thereby construct a replication vector showing cell-specific expression which would not act on normal cells in an adult. The thus constructed vector is transferred into malignant tumor cells to thereby selectively injury tumor cells or proliferative smooth muscle cells in tumor neovessels.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Japan Science And Technology Corporation
  • 発明者(英語)
  • Takahashi, Katsuhito
  • Yamamura, Hisako
  • Miyatake, Shin-Ichi
国際特許分類(IPC)
指定国 CA US
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