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WATER-SOLUBLE DRUG CARRIER AND PROCESS FOR PRODUCTION THEREOF

外国特許コード F110005946
整理番号 QP100027-PC
掲載日 2011年11月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2010JP004021
国際公開番号 WO 2011/004552
国際出願日 平成22年6月16日(2010.6.16)
国際公開日 平成23年1月13日(2011.1.13)
発明の名称 (英語) WATER-SOLUBLE DRUG CARRIER AND PROCESS FOR PRODUCTION THEREOF
発明の概要(英語) Disclosed are: a drug delivery carrier which has no concern about the leakage of a drug therefrom, can control particle sizes thereof easily, is widely applicable even to drugs other than drugs that do not have high anionic properties, besides water-soluble drugs, can deliver water-soluble substances such as genes and proteins, and can be used as a non-viral gene vector; and a process for producing the drug delivery carrier. The drug delivery carrier is characterized in that a water-soluble drug are double-coated with two types of surfactants 1 and 2. The drug delivery carrier can be produced by a process comprising the steps of: 1) mixing an aqueous phase containing the water-soluble drug with an oily phase containing the surfactant 1 while agitating to form a W/O emulsion in which the aqueous phase containing the water-soluble drug is dispersed in the oily phase; 2) removing the inner aqueous phase from the W/O emulsion to form an S/O in which a complex of the water-soluble drug and the surfactant 1 is dispersed in the oily phase; 3) mixing the S/O with an aqueous phase containing the surfactant 2 while agitating to form an S/O/W emulsion in which the S/O is dispersed in the aqueous phase; and 4) removing the inner oily phase from the S/O/W emulsion to form an S/W in which a complex of the water-soluble drug, the surfactant 1 and the surfactant 2 is dispersed in the aqueous phase.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
  • 発明者(英語)
  • GOTO, Masahiro
  • KAMIYA, Noriho
  • TAHARA, Yoshiro
国際特許分類(IPC)
指定国 AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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