TOP > 外国特許検索 > CONSTRUCTION OF EXPRESSION SYSTEM FOR RNA POLYMERASE DERIVED FROM INFLUENZA VIRUS, CRYSTALLIZATION OF THE RNA POLYMERASE, AND SCREENING METHOD FOR ANTI-INFLUENZA AGENT

CONSTRUCTION OF EXPRESSION SYSTEM FOR RNA POLYMERASE DERIVED FROM INFLUENZA VIRUS, CRYSTALLIZATION OF THE RNA POLYMERASE, AND SCREENING METHOD FOR ANTI-INFLUENZA AGENT

外国特許コード F110006001
整理番号 S2008-0612
掲載日 2011年12月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2009JP062140
国際公開番号 WO 2010/001967
国際出願日 平成21年7月2日(2009.7.2)
国際公開日 平成22年1月7日(2010.1.7)
優先権データ
  • 特願2008-173567 (2008.7.2) JP
  • 特願2009-015497 (2009.1.27) JP
発明の名称 (英語) CONSTRUCTION OF EXPRESSION SYSTEM FOR RNA POLYMERASE DERIVED FROM INFLUENZA VIRUS, CRYSTALLIZATION OF THE RNA POLYMERASE, AND SCREENING METHOD FOR ANTI-INFLUENZA AGENT
発明の概要(英語) The object aims to express an RNA polymerase derived from an influenza virus in a large quantity, to crystallize an RNA polymerase derived from an influenza virus, and to provide a method for screening for a substance which can act as an active ingredient for an anti-influenza agent that targets a protein highly conserved among influenza virus species. Disclosed are: a complex which comprises a polypeptide comprising an amino acid sequence lying between position-239 to position-716 in an RNA polymerase PA subunit and a polypeptide comprising an amino acid sequence lying between position-1 to position-81 in an RNA polymerase PB1 subunit of influenza A/PUERTO RICO/8/1934 H1N1 TYPE; and a method for screening for a substance that can act as an active ingredient for an anti-influenza agent, which comprises the step of selecting a substance capable of inhibiting the interaction between .alpha.-subunit and .beta.-subunit 1 both constituting an influenza virus RNA polymerase in the presence of a candidate substance.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TSUKUBA
  • PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
  • 発明者(英語)
  • NAGATA Kyosuke
  • KAWAGUCHI Atsushi
  • PARK Sam-Yong
  • OBAYASHI Eiji
国際特許分類(IPC)
指定国 AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW(UTILITY MODEL),BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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