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Cancer cell migration and cancer cell invasion inhibitor

外国特許コード F120006106
整理番号 S2008-0392
掲載日 2012年1月6日
出願国 アメリカ合衆国
出願番号 93413309
公報番号 20110070163
公報番号 8674079
出願日 平成21年3月19日(2009.3.19)
公報発行日 平成23年3月24日(2011.3.24)
公報発行日 平成26年3月18日(2014.3.18)
国際出願番号 JP2009055479
国際公開番号 WO2009119455
国際出願日 平成21年3月19日(2009.3.19)
国際公開日 平成21年10月1日(2009.10.1)
優先権データ
  • 特願2008-083588 (2008.3.27) JP
  • 2009JP055479 (2009.3.19) WO
発明の名称 (英語) Cancer cell migration and cancer cell invasion inhibitor
発明の概要(英語) Provided are an antibody which binds specifically PAR1 (protease activated receptor 1) or a fragment of the antibody which retains similar characteristics thereto; a composition containing the same for inhibiting the migration activity and invasion activity of cancer cells; and a medicinal composition for treating cancer and the like.
特許請求の範囲(英語) [claim1]
1. A monoclonal antibody produced by a hybridoma having an accession number of FERM BP-11105 assigned by International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, or a antigen-binding antibody fragment thereof.
[claim2]
2. The antibody according to claim 1, wherein the antibody is chimeric or humanized, or a antigen-binding antibody fragment thereof.
[claim3]
3. A composition for inhibiting migration activity and invasion activity of cancer cells, comprising the antibody of claim 1 or antigen-binding antibody fragment thereof.
[claim4]
4. A medicinal composition for treating cancers, comprising the antibody or antigen-binding antibody fragment thereof according to claim 1.
[claim5]
5. A method for treating cancers, which comprises administering an effective amount of a medicinal composition containing the antibody or antigen-binding antibody fragment according to claim 1 to a subject in need of such treatment.
[claim6]
6. A method for imaging tumor cells or a method for detecting a tumor in a sample, which comprises bringing the antibody or antigen-binding antibody fragment according to claim 1 into contact with a sample obtained from a subject to bind it to tumor cells in the sample.
[claim7]
7. An imaging agent for tumor cells, comprising the antibody or a antigen-binding antibody fragment thereof according to claim 1.
[claim8]
8. A method for diagnosing a tumor, which comprises administering the antibody or antigen-binding antibody fragment according to claim 1 to a subject to investigate the binding of the antibody or antigen-binding antibody fragment of the present invention to a tumor tissue in the body.
[claim9]
9. A method for preparing an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using a peptide comprising the amino acid sequence as shown in SEQ ID NO: 1.
[claim10]
10. A method for purifying an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using a peptide comprising the amino acid sequence as shown in SEQ ID NO: 1.
[claim11]
11. A method for preparing an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using the antigenic peptide comprising the amino acid sequence as shown in SEQ ID NO: 1 and a carrier protein.
[claim12]
12. A method for purifying an antibody produced by a hybridoma having an accession number of FERM BP-11105, wherein said method comprises using the antigenic peptide comprising the amino acid sequence as shown in SEQ ID NO: 1 and a carrier protein.
  • 発明者/出願人(英語)
  • GONDA KOHSUKE
  • HIGUCHI HIDEO
  • OHUCHI NORIAKI
  • TAKEDA MOTOHIRO
  • TOHOKU UNIVERSITY
国際特許分類(IPC)
米国特許分類/主・副
  • 530/388.1
  • 424/130.1
  • 435/7.1
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