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Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug 実績あり

外国特許コード F120006245
整理番号 S2009-0108-N0
掲載日 2012年2月17日
出願国 アメリカ合衆国
出願番号 200913130952
公報番号 20110230659
公報番号 9273050
出願日 平成21年11月27日(2009.11.27)
公報発行日 平成23年9月22日(2011.9.22)
公報発行日 平成28年3月1日(2016.3.1)
国際出願番号 JP2009070062
国際公開番号 WO2010061931
国際出願日 平成21年11月27日(2009.11.27)
国際公開日 平成22年6月3日(2010.6.3)
優先権データ
  • 特願2008-303239 (2008.11.27) JP
  • 2009JP070062 (2009.11.27) WO
発明の名称 (英語) Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug 実績あり
発明の概要(英語) Provided is a compound having at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumen formation promoting activity, cell migration promoting activity, and neurocyte growth promoting activity, which is a chemically stable low-molecular-weight substance that has high absorbability and can be supplied stably at a low cost because of its low molecular weight.
A cyclobutyl purine derivative, a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof according to the present invention is a cyclobutyl purine derivative represented by the following general formula (1), a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
It is conventionally known that some derivatives having a nucleic acid bound to then four-membered rings have antiviral action.
Examples of such derivatives include cyclobutyl purine derivatives (see Patent Documents 1 to 3, for example) and oxetanocin derivatives having a nucleic acid bound to their oxetane rings (see Patent Document 4, for example).
On the other hand, as substances that promote angiogenesis, neurocyte growth, and the like, living organism-derived growth factors such as fibroblast growth factors (FGFs), platelet-derived growth factors (PD-ECGFs), vascular endothelial growth factors (VEGFs), and nerve growth factors (NGFs) are known.
Some of these growth factors are used as active ingredients in wound healing agents, hair growth agents, and the like.

CITATION LIST

Patent Documents
Patent Document 1: Japanese Patent No. 2694999
Patent Document 2: Japanese Patent No. 2577640
Patent Document 3: Japanese Patent No. 2962494
Patent Document 4: JP 5 (1993)-32691 A

BRIEF
特許請求の範囲(英語) [claim1]
1. A cyclobutyl purine derivative represented by the following formula (1), a tautomer or a stereoisomer thereof, or a salt thereof:

where: X1 is chlorine;
X2 is NH2;
X3 is a hydrogen atom; and
each of R1 and R2 is C2OH.
[claim2]
2. The cyclobutyl purine derivative according to claim 1, the tautomer or the stereoisomer thereof, or the salt thereof, which is 6-amino-2-chloro-9-[trans-trans-2,3-bis(hydroxymethyl)cyclobutyl]purine a tautomer or a stereoisomer thereof, or a salt, a solvate, or a hydrate thereof.
[claim3]
3. A promoting agent having at least one function selected from the group consisting of an angiogenesis-promoting function, a lumen formation-promoting function, and a neurocyte growth-promoting function, the promoting agent comprising: a cyclobutyl purine derivative that is represented by following formula (1'), a tautomer or a stereoisomer thereof, or a salt thereof:

where: X1' is chlorine;
X2' is NH2;
X3' is a hydrogen atom; and
each of R1' and R2' is CH2OH.
[claim4]
4. A promoting agent having at least one function selected from the group consisting of an angiogenesis-promoting function, a lumen formation-promoting function, and a neurocyte growth-promoting function, the promoting agent comprising: the cyclobutyl purine derivative according to claim 2, the tautomer or the stereoisomer thereof, or the salt thereof.
[claim5]
5. A drug having at least one function selected from the group consisting of promoting angiogenesis, promoting lumen formation, and promoting neurocyte growth, the drug comprising: at least one compound selected from the group consisting of the cyclobutyl purine derivative according to claim 3, the tautomers and the stereoisomers thereof, the salts thereof and
at least, one pharmaceutically acceptable additive.
  • 発明者/出願人(英語)
  • TSUKAMOTO IKUKO
  • KONISHI RYOJI
  • TOKUDA MASAAKI
  • KUBOTA YASUO
  • MARUYAMA TOKUMI
  • KOSAKA HIROAKI
  • IGARASHI JUNSUKE
  • KAGAWA NATIONAL UNIVERSITY
国際特許分類(IPC)
米国特許分類/主・副
  • 544/276
  • 544/277
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