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Method for selectively controlling function of helper t cell

外国特許コード F120006322
整理番号 A261-10WO
掲載日 2012年3月22日
出願国 欧州特許庁(EPO)
出願番号 09823694
公報番号 2363148
公報番号 2363148
出願日 平成21年10月30日(2009.10.30)
公報発行日 平成23年9月7日(2011.9.7)
公報発行日 平成26年11月26日(2014.11.26)
国際出願番号 JP2009068671
国際公開番号 WO2010050584
国際出願日 平成21年10月30日(2009.10.30)
国際公開日 平成22年5月6日(2010.5.6)
優先権データ
  • 2009JP068671 (2009.10.30) WO
  • 特願2008-281890 (2008.10.31) JP
発明の名称 (英語) Method for selectively controlling function of helper t cell
発明の概要(英語) The present invention relates to selectively controlling the function of a helper T cell.
In the present invention, a mouse lacking a gene involved in ganglioside biosynthesis (ganglioside GM3 synthetase gene) (SAT-I KO) was produced and analyzed.
As a result, the present invention provides, for example, a method for screening a substance which induces selective suppression of the function of a helper T cell in an immune response, including control of production of a sphingoglycolipid in the helper T cell, and moderation or suppression of an excessive immune response caused by the suppression of the function, that is, a substance having an immunosuppression activity, an anti-asthmatic action and/or an anti-allergic action.
特許請求の範囲(英語) [claim1]
1. An in vitro method for screening a substance having an immunosuppressive action, an anti-asthmatic action and/or an anti-allergic action, which comprises: contacting a test substance with a helper T cell, measuring the production amount of a GM3 in the helper T cell, and selecting the test substance which suppresses the production amount of GM3 expressed in a helper T cell when compared to a control helper T cell, as having an immunosuppressive action, an anti-asthmatic action and/or an anti-allergic action .
[claim2]
2. An in vitro method for screening a substance having an immunosuppressive action, an anti-asthmatic action and/or an anti-allergic action, which comprises: contacting a test substance with a helper T cell, measuring expression level of GM3 synthetase in the helper T cell, and selecting the test substance which inhibits the expression of the GM3 synthase when compared to a control helper T cell, as having an immunosuppressive action, as having an anti-asthmatic action and/or an anti-allergic action.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • INOKUCHI JINICHI
  • NAGAFUKU MASAKAZU
  • OHNO ISAO
  • OKUYAMA KAORI
国際特許分類(IPC)
指定国 Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA
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