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Method for selective control of helper T cell function

外国特許コード F120006328
整理番号 A261-10WO
掲載日 2012年3月22日
出願国 アメリカ合衆国
出願番号 200913126140
公報番号 20110262441
公報番号 8691514
出願日 平成21年10月30日(2009.10.30)
公報発行日 平成23年10月27日(2011.10.27)
公報発行日 平成26年4月8日(2014.4.8)
国際出願番号 JP2009068671
国際公開番号 WO2010050584
国際出願日 平成21年10月30日(2009.10.30)
国際公開日 平成22年5月6日(2010.5.6)
優先権データ
  • 特願2008-281890 (2008.10.31) JP
  • 2009JP068671 (2009.10.30) WO
発明の名称 (英語) Method for selective control of helper T cell function
発明の概要(英語) The present invention relates to selectively controlling the function of a helper T cell.
In the present invention, a mouse lacking a gene involved in ganglioside biosynthesis (ganglioside GM3 synthetase gene) (SAT-I KO) was produced and analyzed.
As a result, the present invention provides, for example, a method for screening a substance which induces selective suppression of the function of a helper T cell in an immune response, including control of production of a sphingoglycolipid in the helper T cell, and moderation or suppression of an excessive immune response caused by the suppression of the function, that is, a substance having an immunosuppression activity, an anti-asthmatic action and/or an anti-allergic action.
特許請求の範囲(英語) [claim1]
1. A screening method, wherein the method comprises: contacting a test substance with a helper T cell;
measuring the production amount of GM3 in the helper T cell;
selecting the test substance that reduces the amount of GM3 as compared to a control by specifically reducing the GM3 synthase expression in the helper T cell;
administering the selected test substance to a non-human animal having an immune disease, asthma, and/or indicating an allergic reaction; and
selecting the administered test substance that has an immunosuppressive action, an anti-asthmatic action, and/or an anti-allergic action as compared to a control animal.
[claim2]
2. The method according to claim 1, wherein the non-human animal is a mouse.
[claim3]
3. The method according to claim 1, wherein the method further comprises comparing the number of infiltrating cells of macrophages, neutrophils, eosinophils, and/or lymphocytes in an inflammatory site of the non-human animal with that of a control animal.
  • 発明者/出願人(英語)
  • INOKUCHI JINICHI
  • NAGAFUKU MASAKAZU
  • OHNO ISAO
  • OKUYAMA KAORI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 435/7.21
  • 435/7.24
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA
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