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USE OF COMPOUND BINDING TO MSIN3B THAT SPECIFICALLY BINDS TO NEURON RESTRICTIVE SILENCER FACTOR (NRSF)

外国特許コード F120006378
整理番号 S2010-0391-C0
掲載日 2012年3月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP052710
国際公開番号 WO 2011/099502
国際出願日 平成23年2月9日(2011.2.9)
国際公開日 平成23年8月18日(2011.8.18)
優先権データ
  • 特願2010-027066 (2010.2.10) JP
発明の名称 (英語) USE OF COMPOUND BINDING TO MSIN3B THAT SPECIFICALLY BINDS TO NEURON RESTRICTIVE SILENCER FACTOR (NRSF)
発明の概要(英語) The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to a neuron restrictive silencer factor (NRSF), and provides a use of the compound as a prophylactic and/or therapeutic agent for diseases associated with aberrant expression of a neuron restrictive silencer binding factor (NRSF/REST) or aberrant expression of a gene targeted by the NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain. Specifically disclosed is a pharmaceutical composition which contains a substance that is capable of binding to the PAH1 domain of mSin3B, for example, a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof. (In the formula, n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represents a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, a -CONH- group, an -NHCO- group or a sulfonyl group; and Z represents an optionally substituted nitrogen-containing heterocyclic group, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or an optionally substituted nitrogen- and oxygen-containing heterocyclic group.)
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Public University Corporation Yokohama City University
  • Nagasaki University
  • Nagoya City University
  • 発明者(英語)
  • NISHIMURA, Yoshifumi
  • NAGADOI, Aritaka
  • HIRAO, Yuuka
  • GOSHIMA, Yoshio
  • YAMASHITA, Naoya
  • MIYATA, Naoki
  • SUZUKI, Takayoshi
  • HIRAISHI, Ryuta
  • UEDA, Hiroshi
国際特許分類(IPC)
指定国 AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,RS,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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