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Method of reacting two-phase solution changing in phase state with temperature change and apparatus for practicing the same 実績あり

外国特許コード F120006719
整理番号 Y0411US2
掲載日 2012年5月28日
出願国 アメリカ合衆国
出願番号 201113233279
公報番号 20120032110
公報番号 8865475
出願日 平成23年9月15日(2011.9.15)
公報発行日 平成24年2月9日(2012.2.9)
公報発行日 平成26年10月21日(2014.10.21)
国際出願番号 JP2004015096
国際公開番号 WO2005035111
国際出願日 平成16年10月6日(2004.10.6)
国際公開日 平成17年4月21日(2005.4.21)
優先権データ
  • 特願2003-349016 (2003.10.8) JP
  • 特願2003-374234 (2003.11.4) JP
  • 12/574,851 (2007.1.26) US
  • 2004JP015096 (2004.10.6) WO
発明の名称 (英語) Method of reacting two-phase solution changing in phase state with temperature change and apparatus for practicing the same 実績あり
発明の概要(英語) A method for making a number (N) of samples react under the same reaction conditions that includes heating a number of reaction containers simultaneously and maintaining the reaction containers at a predetermined temperature; placing a sample in each heated reaction chamber and maintaining a two-phase solution at a predetermined temperature; stirring the sample that is heated to the predetermined temperature to create a uniform solution, which is maintained for a predetermined time; and cooling the uniform solution without cooling the reaction container after the predetermined period of time has passed so as to gain a two-phase solution within the reaction container, where the samples have a solution where the phase state of a reaction solvent changes in a reversible manner between a two-phase solution state and a uniform solution state when the temperature fluctuates over or under a certain constant temperature.
特許請求の範囲(英語) [claim1]
1. A method, comprising: heating a material solution comprising a reactant and a two-phase reaction solvent comprising a first phase comprising a nonpolar solvent and a second phase comprising a polar solvent to a reaction temperature in a reaction container;
stirring the material solution, such that the first phase and the second phase of the two-phase reaction solvent dissolve each other to form a one-phase solution;
maintaining the one-phase solution, with stirring, at the reaction temperature for a predetermined period of time, to obtain a one-phase product solution comprising a reaction product;
drawing the one-phase product solution within the reaction container into an extraction apparatus and cooling the one-phase product solution outside the reaction container to a predetermined temperature below the reaction temperature without cooling the reaction container, to obtain a two-phase product solution comprising a solvent phase comprising the polar solvent and a product phase comprising the reaction product and the nonpolar solvent; and then,
returning the two-phase product solution, without stirring, to the reaction container, wherein the two-phase product solution is maintained.
[claim2]
2. The method of claim 1, further comprising, after the cooling: extracting the product phase from the two-phase product solution.
[claim3]
3. The method of claim 2, wherein the solvent phase remains in the reaction container after extracting the product phase and is employed as the second phase of the two-phase reaction solvent in a subsequent reaction.
[claim4]
4. The method of claim 1, wherein the first phase of the two-phase reaction solvent comprises a cycloalkane compound, and wherein the second phase of the two-phase reaction solvent comprises at least one selected from a nitroalkane, a nitrile, an alcohol, an alkyl halide, a carbonate, an imidazolidinone, a carbodiimide, an ester, a carboxylic acid, an aldehyde, a ketone, an ether, a urea, an amide, and a sulfoxide.
[claim5]
5. The method of claim 1, wherein the first phase of the two-phase reaction solvent is an alkane, a cycloalkane, an alkene, an alkyne, or an aromatic compound.
[claim6]
6. The method of claim 5, wherein the first phase of the two-phase reaction solvent is a cycloalkane compound.
[claim7]
7. The method of claim 6, wherein the cycloalkane compound is cyclohexane.
[claim8]
8. The method of claim 6, wherein the cycloalkane compound is methyl cyclohexane.
[claim9]
9. The method of claim 6, wherein the cycloalkane compound is decalin.
[claim10]
10. The method of claim 1, wherein the second phase of the two-phase reaction solvent is a nitroalkane, a nitrile, an alcohol, an alkyl halide, a carbonate, an imidazolidinone, a carbodiimide, an ester, a carboxylic acid, an aldehyde, a ketone, an ether, a urea, an amide compound, or a sulfoxide.
[claim11]
11. The method of claim 10, wherein the second phase of the two-phase reaction solvent is an amide compound.
[claim12]
12. The method of claim 11, wherein the amide compound is dimethyl formamide.
[claim13]
13. The method of claim 10, wherein the organic solvent having a high polarity is an imidazolidinone compound.
[claim14]
14. The method of claim 13, wherein the imidazolidinone compound is dimethyl imidazolidinone.
[claim15]
15. The method of claim 6, wherein the second phase of the two-phase reaction solvent is an amide compound.
[claim16]
16. The method of claim 6, wherein the second phase of the two-phase reaction solvent is an imidazolidinone compound.
  • 発明者/出願人(英語)
  • CHIBA KAZUHIRO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • 436/178
  • 436/4
  • 436/177
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