TOP > 外国特許検索 > METHOD FOR ASSAYING HISTONE METHYLATION ENZYME ACTIVITY

METHOD FOR ASSAYING HISTONE METHYLATION ENZYME ACTIVITY

外国特許コード F120006804
整理番号 S2010-0701-C0
掲載日 2012年7月3日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP002231
国際公開番号 WO 2011/132392
国際出願日 平成23年4月15日(2011.4.15)
国際公開日 平成23年10月27日(2011.10.27)
優先権データ
  • 特願2010-202484 (2010.9.9) JP
  • 特願2010-096496 (2010.4.19) JP
発明の名称 (英語) METHOD FOR ASSAYING HISTONE METHYLATION ENZYME ACTIVITY
発明の概要(英語)

Provided are a method for assaying histone methylation enzyme activity, a method for screening for compounds that inhibit histone methylation enzyme activity, a reagent kit for assaying histone methylation enzyme activity, and a kit for screening for compounds that inhibit histone methylation enzyme activity. The compound or salt thereof that serves as the matrix compound for assaying histone methylation enzyme activity is represented by general formula (I) (I) (where, in general formula (I), R1 is a hydrogen atom or amino terminal protector group, X is a peptide comprising zero or one or more amino acid residues, K is a lysine residue, and R2 is a pigment marker that has formed an amide bond with the carbonyl terminal of the lysine residue). When the amide bond is severed by a peptidase, the fluorescent characteristics or coloration characteristics of the pigment marker change, and when the e-amino groups of the lysine residue are methylated by a histone methylation enzyme, there is a reduction in sensitivity to peptidase.R1-X-K-R2

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYUSHU INSTITUTE OF TECHNOLOGY,
  • NISHINO, NORIKAZU,
  • TAKEMOTO, YASUSHI,
  • ITO, AKIHIRO,
  • YOSHIDA, MINORU
  • 発明者(英語)
  • NISHINO, NORIKAZU,
  • TAKEMOTO, YASUSHI,
  • ITO, AKIHIRO,
  • YOSHIDA, MINORU
国際特許分類(IPC)
詳細は、下記「問合せ先」まで直接お問い合わせください。

PAGE TOP

close
close
close
close
close
close