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METHOD FOR REMOVING TUMORIGENESIS-CAUSING CELLS AMONG STEM CELLS

外国特許コード F120006938
整理番号 S2011-0583
掲載日 2012年10月17日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP058414
国際公開番号 WO 2012/133674
国際出願日 平成24年3月29日(2012.3.29)
国際公開日 平成24年10月4日(2012.10.4)
優先権データ
  • 特願2011-073690 (2011.3.29) JP
発明の名称 (英語) METHOD FOR REMOVING TUMORIGENESIS-CAUSING CELLS AMONG STEM CELLS
発明の概要(英語)

The present invention provides a lethal agent for undifferentiated cells and/or cells that would cause tumorigenesis, the lethal agent containing a virus vector in which a promoter for a nucleic acid for encoding an essential factor for replicating or assembling at least one virus has been replaced with a promoter for a gene which is specifically expressed in cancer cells or undifferentiated cells. The present invention further provides a lethal agent for undifferentiated cells and/or cells that would cause tumorigenesis, the lethal agent containing an expression vector including a nucleic acid for encoding a cytotoxic factor under the control of a promoter for a gene which is specifically expressed in cancer cells or undifferentiated cells. The present invention additionally provides a method for producing differentiated cells having a reduced risk of tumorigenesis, the method being characterized in that an aforesaid drug is brought into contact with a cell population induced to differentiate from stem cells, to thereby kill the undifferentiated cells or cells that would cause tumorigenesis remaining within the cell population.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY,
  • KOSAI, KEN-ICHIRO,
  • MITSUI, KAORU
  • 発明者(英語)
  • KOSAI, KEN-ICHIRO,
  • MITSUI, KAORU
国際特許分類(IPC)
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