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METHOD FOR SCREENING BINDING INHIBITOR OF RAGE AND AGE コモンズ

外国特許コード F120006980
整理番号 S2010-1251-C0
掲載日 2012年10月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP071669
国際公開番号 WO 2012/039469
国際出願日 平成23年9月22日(2011.9.22)
国際公開日 平成24年3月29日(2012.3.29)
優先権データ
  • 特願2010-214019 (2010.9.24) JP
発明の名称 (英語) METHOD FOR SCREENING BINDING INHIBITOR OF RAGE AND AGE コモンズ
発明の概要(英語)

Provided is a method for screening a binding inhibitor of RAGE and AGE focused on the new activity of ss-amyloid peptide. Provided is a method for screening a binding inhibitor of RAGE and AGE by sorting candidate compounds inhibiting the activity affecting the binding affinity of RAGE and AGE of ss-amyloid peptide through finding, for the first time, that the ss-amyloid peptide makes the binding of RAGE and AGE change to high binding affinity. The binding inhibitor obtained by this screening method can be used as a therapeutic agent for any diseases or symptoms caused by the binding of RAGE and AGE in which ss-amyloid peptide involves. Especially, the binding inhibitor is capable of contributing to the development of the therapeutic drug for Alzheimer's disease focused on the new mechanism.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY,
  • NISHIBORI, MASAHIRO,
  • MORI, SHUJI,
  • TAKAHASHI, HIDEO,
  • WAKE, HIDENORI,
  • LIU, KEYUE
  • 発明者(英語)
  • NISHIBORI, MASAHIRO,
  • TAKAHASHI, HIDEO,
  • WAKE, HIDENORI,
  • LIU, KEYUE
国際特許分類(IPC)

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