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DIAGNOSTIC METHOD FOR CHRONIC INFLAMMATORY DISEASES USING ANTIBODY AGAINST INHIBITORY CO-STIMULATORY MOLECULES AS MARKER

外国特許コード F130007167
整理番号 S2011-0242-C0
掲載日 2013年2月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP076507
国際公開番号 WO 2012/086346
国際出願日 平成23年11月17日(2011.11.17)
国際公開日 平成24年6月28日(2012.6.28)
優先権データ
  • 特願2010-286456 (2010.12.22) JP
発明の名称 (英語) DIAGNOSTIC METHOD FOR CHRONIC INFLAMMATORY DISEASES USING ANTIBODY AGAINST INHIBITORY CO-STIMULATORY MOLECULES AS MARKER
発明の概要(英語)

Provided is a diagnostic method for chronic inflammatory diseases, the main condition of which is lymphocyte infiltration. Specifically provided is a diagnostic method which is capable of distinguishing chronic inflammatory diseases, the main condition of which is lymphocyte infiltration, from acute inflammation and inflammatory diseases, the main condition of which is not lymphocyte infiltration, said distinguishment having been impossible by conventional inflammation markers. The diagnostic method is enabled by measuring an antibody against inhibitory co-stimulatory molecules (such as PD-1, BTLA or CTLA-4) expressed in T cells and/or B cells. This diagnostic method enables distinguishment of chronic inflammatory diseases, the main condition of which is lymphocyte infiltration, from acute inflammation and inflammatory diseases, the main condition of which is not lymphocyte infiltration. A remarkable difference can be recognized among diseases that have similar clinical conditions by measuring the antibody, so that distinguishment among such diseases becomes possible.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY,
  • MIYAKE, YASUHIRO,
  • YAMAMOTO, KAZUHIDE,
  • MATSUMOTO, KAZUYUKI
  • 発明者(英語)
  • MIYAKE, YASUHIRO,
  • YAMAMOTO, KAZUHIDE,
  • MATSUMOTO, KAZUYUKI
国際特許分類(IPC)

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