TOP > 外国特許検索 > METHOD FOR SCREENING SUBSTANCE RELATING TO ENDOPLASMIC RETICULUM STRESS PARTICIPATING IN ONSET OF DIABETES

METHOD FOR SCREENING SUBSTANCE RELATING TO ENDOPLASMIC RETICULUM STRESS PARTICIPATING IN ONSET OF DIABETES

外国特許コード F130007206
整理番号 S2011-0221-C0
掲載日 2013年3月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP052650
国際公開番号 WO 2012/108394
国際出願日 平成24年2月6日(2012.2.6)
国際公開日 平成24年8月16日(2012.8.16)
優先権データ
  • 特願2011-023697 (2011.2.7) JP
発明の名称 (英語) METHOD FOR SCREENING SUBSTANCE RELATING TO ENDOPLASMIC RETICULUM STRESS PARTICIPATING IN ONSET OF DIABETES
発明の概要(英語)

The purpose of the present invention is to provide a system for evaluating the activation of an ATF6-mediated pathway. Namely, provided is a method for screening an endoplasmic reticulum stressor that is capable of activating the ATF6-mediated pathway. Also provided are a method for screening a substance that is capable of regulating endoplasmic reticulum stress induced by the activation of the ATF6-mediated pathway, and a method for screening an antidiabetic drug candidate. As the results of intensive studies, the present inventors found that the activation of the ATF6-mediated pathway can be evaluated in the state of vital cells in real time at a high sensitivity by using a polynucleotide that encodes a non-fluorescent peptide domain derived from a fluorescent protein and an ATF6 protein domain.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • THE UNIVERSITY OF TOKUSHIMA,
  • OYADOMARI, SEIICHI
  • 発明者(英語)
  • OYADOMARI, SEIICHI
国際特許分類(IPC)
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