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CELL-SPECIFIC EXPRESSION/REPLICATION VECTOR

外国特許コード F040000725
整理番号 F040000725
掲載日 2005年4月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2002JP013683
国際公開番号 WO 2003/057888
国際出願日 平成14年12月26日(2002.12.26)
国際公開日 平成15年7月17日(2003.7.17)
優先権データ
  • 特願2001-402102 (2001.12.28) JP
  • 特願2002-255395 (2002.8.30) JP
発明の名称 (英語) CELL-SPECIFIC EXPRESSION/REPLICATION VECTOR
発明の概要(英語) It is intended to provide a therapeutic method comprising constructing a cell-specific expression/replication vector usable in treating malignant tumor, etc. which is capable of expressing and replicating a gene in specific cells such as a malignant tumor without injuring normal cells (in particular, a vector capable of regulating the expression/replication at a desired point after the expression/replication) and transferring the vector into specific cells such as a malignant tumor in vivo followed by the expression thereof. The transcription initiation regulating domain of a human calponin gene which is cell-specifically expressed is acquired and ligated to the upstream of a viral replication-associated gene such as ICP4. Then a DNA encoding a protein such as an angiogenesis regulator or an apoptosis-associated factor is ligated to the viral replication-associated gene as described above via IRES, while a thymidine kinase gene in an intact state is integrated into a viral DNA. Thus a cell-specific expression/replication vector not acting on adult normal cells is constructed. The thus constructed vector is transfected into malignant tumor cells so as to selectively disrupt the malignant tumor cells.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Japan Science And Technology Corporation
  • 発明者(英語)
  • Takahashi, Katsuhito
  • Yamamura, Hisako
国際特許分類(IPC)
指定国 CA US AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR
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